Binding-driven forward tearing protospacer activated CRISPR-Cas12a system and applications for microRNA detection

Binding-driven forward tearing protospacer activated CRISPR-Cas12a system and applications for microRNA detection

Abstract CRISPR-Cas12a system, characterized by its precise sequence recognition and cleavage activity, has emerged as a powerful and programmable tool for molecular diagnostics. However, current CRISPR-Cas12a-based nucleic acid detection methods, particularly microRNA (miRNA) detection, necessitate...

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Bibliographic Details
Main Authors: Lina Zhao, Xiangyu Deng, Yuqing Li, Qing Zhao, Lizhu Xiao, Jianjiang Xue, Anyi Chen, Wei Cheng, Min Zhao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
CRISPR-Cas12a
MicroRNA
Hairpin DNA
Biosensing
Online Access:https://doi.org/10.1186/s12951-024-02915-5
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