Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique
In current article an easy and selective method is proposed for spectrophotometric estimation of metoclopramide (MCP) in pharmaceutical preparations using cloud point extraction (CPE) procedure. The method involved reaction between MCP with 1-Naphthol in alkali conditions using Triton X-114 to form...
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| Language: | English |
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University of Baghdad, College of Science for Women
2020-03-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3017 |
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| author | maha Al-Tameemi |
| author_facet | maha Al-Tameemi |
| author_sort | maha Al-Tameemi |
| collection | DOAJ |
| description | In current article an easy and selective method is proposed for spectrophotometric estimation of metoclopramide (MCP) in pharmaceutical preparations using cloud point extraction (CPE) procedure. The method involved reaction between MCP with 1-Naphthol in alkali conditions using Triton X-114 to form a stable dark purple dye. The Beer’s law limit in the range 0.34-9 μg mL-1 of MCP with r =0.9959 (n=3) after optimization. The relative standard deviation (RSD) and percentage recoveries were 0.89 %, and (96.99–104.11%) respectively. As well, using surfactant cloud point extraction as a method to extract MCP was reinforced the extinction coefficient(ε) to 1.7333×105L/mol.cm in surfactant-rich phase. The small volume of organic solvent (500mL/sample) provides an environmentally friendly and low-cost preconcentration method. The suggested method was utilized for analyzing of MCP in commercial pharmaceutical injections. |
| format | Article |
| id | doaj-art-25b7ec45bf8d4d8da874eb484f7af6c8 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-25b7ec45bf8d4d8da874eb484f7af6c82025-08-20T02:52:46ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862020-03-0117110.21123/bsj.2020.17.1.0057Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Techniquemaha Al-TameemiIn current article an easy and selective method is proposed for spectrophotometric estimation of metoclopramide (MCP) in pharmaceutical preparations using cloud point extraction (CPE) procedure. The method involved reaction between MCP with 1-Naphthol in alkali conditions using Triton X-114 to form a stable dark purple dye. The Beer’s law limit in the range 0.34-9 μg mL-1 of MCP with r =0.9959 (n=3) after optimization. The relative standard deviation (RSD) and percentage recoveries were 0.89 %, and (96.99–104.11%) respectively. As well, using surfactant cloud point extraction as a method to extract MCP was reinforced the extinction coefficient(ε) to 1.7333×105L/mol.cm in surfactant-rich phase. The small volume of organic solvent (500mL/sample) provides an environmentally friendly and low-cost preconcentration method. The suggested method was utilized for analyzing of MCP in commercial pharmaceutical injections.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3017Cloud point extraction, Metoclopramide hydrochloride detection, 1-Naphthol, Pharmaceutical products, Spectrophotometry. |
| spellingShingle | maha Al-Tameemi Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique مجلة بغداد للعلوم Cloud point extraction, Metoclopramide hydrochloride detection, 1-Naphthol, Pharmaceutical products, Spectrophotometry. |
| title | Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique |
| title_full | Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique |
| title_fullStr | Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique |
| title_full_unstemmed | Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique |
| title_short | Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique |
| title_sort | surfactant cloud point extraction as a procedure of preconcentrating for metoclopramide determination using spectro analytical technique |
| topic | Cloud point extraction, Metoclopramide hydrochloride detection, 1-Naphthol, Pharmaceutical products, Spectrophotometry. |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3017 |
| work_keys_str_mv | AT mahaaltameemi surfactantcloudpointextractionasaprocedureofpreconcentratingformetoclopramidedeterminationusingspectroanalyticaltechnique |