Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico
Background and objectives: The correlation between diminished 25-hydroxyvitamin D (25-(OH)D) concentrations and heightened disease activity in systemic lupus erythematosus (SLE) patients remains contentious, as clinical studies have yielded conflicting outcomes—some propose a potential link, while o...
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2024-12-01
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| author | Daniela Deossa-Piedrahita Berenice Vicente-Hernández Sol Ramírez-Ochoa Mauricio Alfredo Ambriz-Alarcón Gabino Cervantes-Pérez Gabino Cervantes-Guevara Alejandro González-Ojeda Clotilde Fuentes-Orozco Francisco Javier Hernández-Mora Luis Asdruval Zepeda-Gutiérrez Jorge Isaac Michel-González Janet Cristina Vázquez-Beltrán Enrique Cervantes-Pérez |
| author_facet | Daniela Deossa-Piedrahita Berenice Vicente-Hernández Sol Ramírez-Ochoa Mauricio Alfredo Ambriz-Alarcón Gabino Cervantes-Pérez Gabino Cervantes-Guevara Alejandro González-Ojeda Clotilde Fuentes-Orozco Francisco Javier Hernández-Mora Luis Asdruval Zepeda-Gutiérrez Jorge Isaac Michel-González Janet Cristina Vázquez-Beltrán Enrique Cervantes-Pérez |
| author_sort | Daniela Deossa-Piedrahita |
| collection | DOAJ |
| description | Background and objectives: The correlation between diminished 25-hydroxyvitamin D (25-(OH)D) concentrations and heightened disease activity in systemic lupus erythematosus (SLE) patients remains contentious, as clinical studies have yielded conflicting outcomes—some propose a potential link, while others assert no relationship exists. Nonetheless, all studies report a significant prevalence of low 25-(OH)D levels among SLE patients. This study aimed to assess the frequency of low serum levels of 25-(OH)D in Mexican patients with SLE and to evaluate the correlation between 25-(OH)D deficiency or insufficiency and disease activity levels. Materials and Methods: This retrospective analysis comprised patients admitted to our hospital from November 2022 to October 2023, diagnosed with SLE, and had their serum 25-(OH)D levels tested upon admission. The frequency of low levels of 25-(OH)D was assessed, and clinical and demographic data were gathered to examine potential causes linked to 25-(OH)D deficiency or insufficiency. Results: A total of 61 patients were included, and 87% (n = 53) had low serum 25-(OH)D levels. Patients with 25-(OH)D deficiency (n = 21) were significantly younger (mean 23 vs. 39 years, <i>p</i> = 0.04) and had higher protein levels in 24 h urine protein (1.8 vs. 1.1 g/24 h, <i>p</i> = 0.006) than patients who presented only 25-(OH)D insufficiency, without significant differences in other indicators of disease activity. Conclusions: In this investigation, patients with SLE exhibited a high frequency of low serum levels of 25-(OH)D, consistent with existing literature; however, no significant correlations were identified between 25-(OH)D levels and indicators of disease activity. These findings require validation in subsequent research. |
| format | Article |
| id | doaj-art-25b49560dd0c46e3884b5e67fcf2b792 |
| institution | DOAJ |
| issn | 2079-9721 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-25b49560dd0c46e3884b5e67fcf2b7922025-08-20T02:57:13ZengMDPI AGDiseases2079-97212024-12-01121231910.3390/diseases12120319Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western MexicoDaniela Deossa-Piedrahita0Berenice Vicente-Hernández1Sol Ramírez-Ochoa2Mauricio Alfredo Ambriz-Alarcón3Gabino Cervantes-Pérez4Gabino Cervantes-Guevara5Alejandro González-Ojeda6Clotilde Fuentes-Orozco7Francisco Javier Hernández-Mora8Luis Asdruval Zepeda-Gutiérrez9Jorge Isaac Michel-González10Janet Cristina Vázquez-Beltrán11Enrique Cervantes-Pérez12Department of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDivisión de Servicios Intermedios, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDepartment of Gastroenterology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoBiomedical Research Unit 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, Guadalajara 44350, JAL, MexicoBiomedical Research Unit 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, Guadalajara 44350, JAL, MexicoDepartment of Human Reproduction, Growth and Child Development, Health Sciences University Center, Universidad de Guadalajara, Guadalajara 44280, JAL, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoSchool of Medicine, Instituto Politécnico Nacional, Mexico City 11340, CDMX, MexicoDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, JAL, MexicoBackground and objectives: The correlation between diminished 25-hydroxyvitamin D (25-(OH)D) concentrations and heightened disease activity in systemic lupus erythematosus (SLE) patients remains contentious, as clinical studies have yielded conflicting outcomes—some propose a potential link, while others assert no relationship exists. Nonetheless, all studies report a significant prevalence of low 25-(OH)D levels among SLE patients. This study aimed to assess the frequency of low serum levels of 25-(OH)D in Mexican patients with SLE and to evaluate the correlation between 25-(OH)D deficiency or insufficiency and disease activity levels. Materials and Methods: This retrospective analysis comprised patients admitted to our hospital from November 2022 to October 2023, diagnosed with SLE, and had their serum 25-(OH)D levels tested upon admission. The frequency of low levels of 25-(OH)D was assessed, and clinical and demographic data were gathered to examine potential causes linked to 25-(OH)D deficiency or insufficiency. Results: A total of 61 patients were included, and 87% (n = 53) had low serum 25-(OH)D levels. Patients with 25-(OH)D deficiency (n = 21) were significantly younger (mean 23 vs. 39 years, <i>p</i> = 0.04) and had higher protein levels in 24 h urine protein (1.8 vs. 1.1 g/24 h, <i>p</i> = 0.006) than patients who presented only 25-(OH)D insufficiency, without significant differences in other indicators of disease activity. Conclusions: In this investigation, patients with SLE exhibited a high frequency of low serum levels of 25-(OH)D, consistent with existing literature; however, no significant correlations were identified between 25-(OH)D levels and indicators of disease activity. These findings require validation in subsequent research.https://www.mdpi.com/2079-9721/12/12/31925-hydroxyvitamin Ddisease activitysystemic lupus erythematosusvitamin D |
| spellingShingle | Daniela Deossa-Piedrahita Berenice Vicente-Hernández Sol Ramírez-Ochoa Mauricio Alfredo Ambriz-Alarcón Gabino Cervantes-Pérez Gabino Cervantes-Guevara Alejandro González-Ojeda Clotilde Fuentes-Orozco Francisco Javier Hernández-Mora Luis Asdruval Zepeda-Gutiérrez Jorge Isaac Michel-González Janet Cristina Vázquez-Beltrán Enrique Cervantes-Pérez Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico Diseases 25-hydroxyvitamin D disease activity systemic lupus erythematosus vitamin D |
| title | Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico |
| title_full | Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico |
| title_fullStr | Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico |
| title_full_unstemmed | Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico |
| title_short | Serum 25-Hydroxyvitamin D Levels and Disease Activity in Patients with Systemic Lupus Erythematosus: An Exploratory Study in Western Mexico |
| title_sort | serum 25 hydroxyvitamin d levels and disease activity in patients with systemic lupus erythematosus an exploratory study in western mexico |
| topic | 25-hydroxyvitamin D disease activity systemic lupus erythematosus vitamin D |
| url | https://www.mdpi.com/2079-9721/12/12/319 |
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