Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models
Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, consid...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/14/6/593 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467424196263936 |
|---|---|
| author | Abdulrahman M. Busayli Wenhua Xu Ghaidaa A. Raffah Gang Chen |
| author_facet | Abdulrahman M. Busayli Wenhua Xu Ghaidaa A. Raffah Gang Chen |
| author_sort | Abdulrahman M. Busayli |
| collection | DOAJ |
| description | Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, considerable attention has been focused on the influence of gut microbiome on brain development through the gut–brain axis. Changes in the gut microbiome resulting from ethanol exposure may contribute to the pathology of FASD, potentially involving neuroinflammation. This literature review summarizes the existing research and primary animal studies on the impact of early ethanol exposure on the gut microbiome, neuroinflammation, brain development, and behavioral consequences. The evidence suggests that early ethanol exposure alters the gut microbiome, which may induce neuroinflammation, brain damage, and cognitive impairment. However, a clear causal relationship among these factors remains to be fully elucidated. |
| format | Article |
| id | doaj-art-25b405a2280e49759c859c6abbca64db |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-25b405a2280e49759c859c6abbca64db2025-08-20T03:26:15ZengMDPI AGBiology2079-77372025-05-0114659310.3390/biology14060593Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent ModelsAbdulrahman M. Busayli0Wenhua Xu1Ghaidaa A. Raffah2Gang Chen3Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USAFetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, considerable attention has been focused on the influence of gut microbiome on brain development through the gut–brain axis. Changes in the gut microbiome resulting from ethanol exposure may contribute to the pathology of FASD, potentially involving neuroinflammation. This literature review summarizes the existing research and primary animal studies on the impact of early ethanol exposure on the gut microbiome, neuroinflammation, brain development, and behavioral consequences. The evidence suggests that early ethanol exposure alters the gut microbiome, which may induce neuroinflammation, brain damage, and cognitive impairment. However, a clear causal relationship among these factors remains to be fully elucidated.https://www.mdpi.com/2079-7737/14/6/593ethanolfetal alcohol spectrum disordersgut microbiomeneuroinflammationshort-chain fatty acidsbrain |
| spellingShingle | Abdulrahman M. Busayli Wenhua Xu Ghaidaa A. Raffah Gang Chen Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models Biology ethanol fetal alcohol spectrum disorders gut microbiome neuroinflammation short-chain fatty acids brain |
| title | Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models |
| title_full | Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models |
| title_fullStr | Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models |
| title_full_unstemmed | Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models |
| title_short | Gut Microbiome, Neuroinflammation, and Fetal Alcohol Spectrum Disorders: Insights from Rodent Models |
| title_sort | gut microbiome neuroinflammation and fetal alcohol spectrum disorders insights from rodent models |
| topic | ethanol fetal alcohol spectrum disorders gut microbiome neuroinflammation short-chain fatty acids brain |
| url | https://www.mdpi.com/2079-7737/14/6/593 |
| work_keys_str_mv | AT abdulrahmanmbusayli gutmicrobiomeneuroinflammationandfetalalcoholspectrumdisordersinsightsfromrodentmodels AT wenhuaxu gutmicrobiomeneuroinflammationandfetalalcoholspectrumdisordersinsightsfromrodentmodels AT ghaidaaaraffah gutmicrobiomeneuroinflammationandfetalalcoholspectrumdisordersinsightsfromrodentmodels AT gangchen gutmicrobiomeneuroinflammationandfetalalcoholspectrumdisordersinsightsfromrodentmodels |