Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease
Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills and eventually the ability to carry out daily tasks. Chrysoeriol is a flavone compound that exhibits neuroprotective, anti-inflammatory, cholinesterase inhibitor and antioxidant properties. The potential targets...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
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| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/23/bioconf_nittebio2025_02009.pdf |
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| author | D Hariharasudhan M Sharmila M Srihari Prabhu Puniethaa Balakrishnan Rengesh Sabapathi S. Nadana |
| author_facet | D Hariharasudhan M Sharmila M Srihari Prabhu Puniethaa Balakrishnan Rengesh Sabapathi S. Nadana |
| author_sort | D Hariharasudhan |
| collection | DOAJ |
| description | Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills and eventually the ability to carry out daily tasks. Chrysoeriol is a flavone compound that exhibits neuroprotective, anti-inflammatory, cholinesterase inhibitor and antioxidant properties. The potential targets of Alzheimer’s disease were identified by Network Pharmacology. As a result of the analysis, 35 overlapping targets among 100 potential targets for chrysoeriol and 1255 for Alzheimer’s disease were identified. Among the 35 overlapping targets, the Hub genes are highly enriched in the Biological Process, Cellular Component and Molecular Function were analyzed. Further the Molecular Docking analysis revealed that PTGS2, MMP2 and KDR have good binding affinity. It’s shown that chrysoeriol has promising role in modulating key pathways involved in Alzheimer’s disease pathogenesis, paving the way for further experimental validation and drug development. |
| format | Article |
| id | doaj-art-25b3dfd50f574b52a22eba39fa2dae54 |
| institution | DOAJ |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-25b3dfd50f574b52a22eba39fa2dae542025-08-20T03:06:28ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011720200910.1051/bioconf/202517202009bioconf_nittebio2025_02009Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s DiseaseD Hariharasudhan0M Sharmila1M Srihari2Prabhu Puniethaa3Balakrishnan Rengesh4Sabapathi S. Nadana5Department of Biotechnology, K. S. Rangasamy College of TechnologyDepartment of Biotechnology, K. S. Rangasamy College of TechnologyDepartment of Biotechnology, K. S. Rangasamy College of TechnologyDepartment of Biotechnology, K. S. Rangasamy College of TechnologyDepartment of Biotechnology, K. S. Rangasamy College of TechnologyDepartment of Biotechnology, K. S. Rangasamy College of TechnologyAlzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills and eventually the ability to carry out daily tasks. Chrysoeriol is a flavone compound that exhibits neuroprotective, anti-inflammatory, cholinesterase inhibitor and antioxidant properties. The potential targets of Alzheimer’s disease were identified by Network Pharmacology. As a result of the analysis, 35 overlapping targets among 100 potential targets for chrysoeriol and 1255 for Alzheimer’s disease were identified. Among the 35 overlapping targets, the Hub genes are highly enriched in the Biological Process, Cellular Component and Molecular Function were analyzed. Further the Molecular Docking analysis revealed that PTGS2, MMP2 and KDR have good binding affinity. It’s shown that chrysoeriol has promising role in modulating key pathways involved in Alzheimer’s disease pathogenesis, paving the way for further experimental validation and drug development.https://www.bio-conferences.org/articles/bioconf/pdf/2025/23/bioconf_nittebio2025_02009.pdfalzheimer’s diseasechrysoeriolnetwork pharmacologyhub genesmolecular docking |
| spellingShingle | D Hariharasudhan M Sharmila M Srihari Prabhu Puniethaa Balakrishnan Rengesh Sabapathi S. Nadana Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease BIO Web of Conferences alzheimer’s disease chrysoeriol network pharmacology hub genes molecular docking |
| title | Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease |
| title_full | Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease |
| title_fullStr | Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease |
| title_full_unstemmed | Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease |
| title_short | Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease |
| title_sort | network pharmacology and molecular docking analysis of chrysoeriol for alzheimer s disease |
| topic | alzheimer’s disease chrysoeriol network pharmacology hub genes molecular docking |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/23/bioconf_nittebio2025_02009.pdf |
| work_keys_str_mv | AT dhariharasudhan networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease AT msharmila networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease AT msrihari networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease AT prabhupuniethaa networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease AT balakrishnanrengesh networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease AT sabapathisnadana networkpharmacologyandmoleculardockinganalysisofchrysoeriolforalzheimersdisease |