Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients
ABSTRACT: Background: One major challenge in cardiovascular magnetic resonance is reducing scan times to be more compatible with clinical workflows. In 3D magnetic resonance imaging (MRI), strategies to shorten scan times mostly rely on ECG‐triggering or self-navigation for motion management, but a...
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Elsevier
2025-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S109766472500016X |
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| author | Ludovica Romanin Milan Prsa Christopher W. Roy Xavier Sieber Jérôme Yerly Bastien Milani Tobias Rutz Salim Si-mohamed Estelle Tenisch Davide Piccini Matthias Stuber |
| author_facet | Ludovica Romanin Milan Prsa Christopher W. Roy Xavier Sieber Jérôme Yerly Bastien Milani Tobias Rutz Salim Si-mohamed Estelle Tenisch Davide Piccini Matthias Stuber |
| author_sort | Ludovica Romanin |
| collection | DOAJ |
| description | ABSTRACT: Background: One major challenge in cardiovascular magnetic resonance is reducing scan times to be more compatible with clinical workflows. In 3D magnetic resonance imaging (MRI), strategies to shorten scan times mostly rely on ECG‐triggering or self-navigation for motion management, but are affected by heart rate variabilities or respiratory drifts. A similarity-driven multi-dimensional binning algorithm (SIMBA) was introduced for 3D whole-heart angiography from ferumoxytol-enhanced free-running MRI. This study explores acceleration limits using SIMBA, and its compressed-sensing extension extra-dimensional motion-compensation (XD-MC)-SIMBA, while preserving image quality. Methods: Data from 6-min free-running acquisitions of 30 congenital heart disease (CHD) patients were retrospectively undersampled to simulate 5-, 4-, 3-, 2-, and 1-min datasets. SIMBA and XD-MC-SIMBA reconstructions were applied. and the consistency of the data selection together with sharpness metrics were computed as a function of undersampling. Image quality was rated on a 5-point Likert scale. Shorter 3-minute acquisitions were prospectively acquired in nine CHD patients. Results: SIMBA's motion state selection was consistent across undersampling levels, with only 2 of 30 cases showing completely different selections. Image quality metrics decreased with increased undersampling, with SIMBA scoring lower compared to XD-MC-SIMBA. The diagnostic quality was good, with lower scores for 2- and 1-min datasets. Using XD-MC-SIMBA, 43% (31/72) of cases showed improved scores compared to SIMBA and 58% (7/12) of 1-min datasets improved to good or excellent quality. Conclusions: This study demonstrates that ferumoxytol-enhanced free-running MRI can be highly accelerated for 3D angiography in CHD.With the aid of compressed sensing, XD-MC-SIMBA supports the acceleration down to 3 minutes or less. |
| format | Article |
| id | doaj-art-25b36c216cdb43b48c10afc032d9f6d4 |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-25b36c216cdb43b48c10afc032d9f6d42025-08-20T02:34:15ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472025-01-0127110185410.1016/j.jocmr.2025.101854Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patientsLudovica Romanin0Milan Prsa1Christopher W. Roy2Xavier Sieber3Jérôme Yerly4Bastien Milani5Tobias Rutz6Salim Si-mohamed7Estelle Tenisch8Davide Piccini9Matthias Stuber10Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, SwitzerlandDivision of Pediatric Cardiology, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; University Lyon, INSA-Lyon, University Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS, Villeurbanne, France; Department of Radiology, Louis Pradel Hospital, Bron, FranceDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Corresponding author.ABSTRACT: Background: One major challenge in cardiovascular magnetic resonance is reducing scan times to be more compatible with clinical workflows. In 3D magnetic resonance imaging (MRI), strategies to shorten scan times mostly rely on ECG‐triggering or self-navigation for motion management, but are affected by heart rate variabilities or respiratory drifts. A similarity-driven multi-dimensional binning algorithm (SIMBA) was introduced for 3D whole-heart angiography from ferumoxytol-enhanced free-running MRI. This study explores acceleration limits using SIMBA, and its compressed-sensing extension extra-dimensional motion-compensation (XD-MC)-SIMBA, while preserving image quality. Methods: Data from 6-min free-running acquisitions of 30 congenital heart disease (CHD) patients were retrospectively undersampled to simulate 5-, 4-, 3-, 2-, and 1-min datasets. SIMBA and XD-MC-SIMBA reconstructions were applied. and the consistency of the data selection together with sharpness metrics were computed as a function of undersampling. Image quality was rated on a 5-point Likert scale. Shorter 3-minute acquisitions were prospectively acquired in nine CHD patients. Results: SIMBA's motion state selection was consistent across undersampling levels, with only 2 of 30 cases showing completely different selections. Image quality metrics decreased with increased undersampling, with SIMBA scoring lower compared to XD-MC-SIMBA. The diagnostic quality was good, with lower scores for 2- and 1-min datasets. Using XD-MC-SIMBA, 43% (31/72) of cases showed improved scores compared to SIMBA and 58% (7/12) of 1-min datasets improved to good or excellent quality. Conclusions: This study demonstrates that ferumoxytol-enhanced free-running MRI can be highly accelerated for 3D angiography in CHD.With the aid of compressed sensing, XD-MC-SIMBA supports the acceleration down to 3 minutes or less.http://www.sciencedirect.com/science/article/pii/S109766472500016XFerumoxytolWhole-heartCardiac MRICMR3D angiographyPediatric MR |
| spellingShingle | Ludovica Romanin Milan Prsa Christopher W. Roy Xavier Sieber Jérôme Yerly Bastien Milani Tobias Rutz Salim Si-mohamed Estelle Tenisch Davide Piccini Matthias Stuber Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients Journal of Cardiovascular Magnetic Resonance Ferumoxytol Whole-heart Cardiac MRI CMR 3D angiography Pediatric MR |
| title | Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients |
| title_full | Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients |
| title_fullStr | Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients |
| title_full_unstemmed | Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients |
| title_short | Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients |
| title_sort | exploring the limits of scan time reduction for ferumoxytol enhanced whole heart angiography in congenital heart disease patients |
| topic | Ferumoxytol Whole-heart Cardiac MRI CMR 3D angiography Pediatric MR |
| url | http://www.sciencedirect.com/science/article/pii/S109766472500016X |
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