Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature
Synthetic cannabinoids (SCs) abuse is on the rise because they are easily obtained over the counter; they are potent psychoactive compounds and routine drug testing does not detect them. As their abuse is on the rise, so are their detrimental side effects; however, the occurrence of acute hepatitis...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/9627452 |
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| author | Kurt J. Knowles Eric X. Wei Abhishek Seth John Bienvenu James Morris Kenneth Manas Paul Jordan Moheb Boktor |
| author_facet | Kurt J. Knowles Eric X. Wei Abhishek Seth John Bienvenu James Morris Kenneth Manas Paul Jordan Moheb Boktor |
| author_sort | Kurt J. Knowles |
| collection | DOAJ |
| description | Synthetic cannabinoids (SCs) abuse is on the rise because they are easily obtained over the counter; they are potent psychoactive compounds and routine drug testing does not detect them. As their abuse is on the rise, so are their detrimental side effects; however, the occurrence of acute hepatitis due to SCs abuse has been reported only once before. In this case, testing revealed that the patient was also heterozygous for alpha-1-antitrypsin (A-1-AT) with the phenotype of PI⁎EM. This mutant phenotype has never been reported as a cause of A-1-AT disease and the abuse of SCs in a patient with this phenotype has also never been reported. This case illustrates the possible need to expand routine drug testing for SCs and consider A-1-AT phenotyping in certain clinical scenarios. |
| format | Article |
| id | doaj-art-25b2643da6e44107b10ed3b4aef83efd |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-25b2643da6e44107b10ed3b4aef83efd2025-02-03T05:51:42ZengWileyCase Reports in Hepatology2090-65872090-65952017-01-01201710.1155/2017/96274529627452Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the LiteratureKurt J. Knowles0Eric X. Wei1Abhishek Seth2John Bienvenu3James Morris4Kenneth Manas5Paul Jordan6Moheb Boktor7Department of Pathology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Pathology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USADepartment of Gastroenterology and Hepatology, Louisiana State University Health Science Center, Shreveport, LA 71103, USASynthetic cannabinoids (SCs) abuse is on the rise because they are easily obtained over the counter; they are potent psychoactive compounds and routine drug testing does not detect them. As their abuse is on the rise, so are their detrimental side effects; however, the occurrence of acute hepatitis due to SCs abuse has been reported only once before. In this case, testing revealed that the patient was also heterozygous for alpha-1-antitrypsin (A-1-AT) with the phenotype of PI⁎EM. This mutant phenotype has never been reported as a cause of A-1-AT disease and the abuse of SCs in a patient with this phenotype has also never been reported. This case illustrates the possible need to expand routine drug testing for SCs and consider A-1-AT phenotyping in certain clinical scenarios.http://dx.doi.org/10.1155/2017/9627452 |
| spellingShingle | Kurt J. Knowles Eric X. Wei Abhishek Seth John Bienvenu James Morris Kenneth Manas Paul Jordan Moheb Boktor Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature Case Reports in Hepatology |
| title | Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature |
| title_full | Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature |
| title_fullStr | Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature |
| title_full_unstemmed | Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature |
| title_short | Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature |
| title_sort | synthetic cannabinoid abuse and a rare alpha 1 antitrypsin mutant causing acute fulminant hepatitis a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2017/9627452 |
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