Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
Abstract Objectives To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demog...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-024-03468-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544416359088128 |
|---|---|
| author | Juan Molina-Collada Marta Domínguez-Álvaro Rafael B. Melero-González Eugenio de Miguel Maite Silva-Díaz Jesús Alejandro Valero Jaimes Ismael González Julio Sánchez Martín Javier Narváez Joan Calvet Ivette Casafont-Solé Jose A Román Ivorra Selene Labrada Arrabal Margarida Vasques Rocha Carlota L Iñiguez María Sagrario Bustabad Reyes Cristina Campos Fernández María Alcalde Villar Antonio Juan Mas Ricardo Blanco on behalf of the ARTESER Project Collaborative Group |
| author_facet | Juan Molina-Collada Marta Domínguez-Álvaro Rafael B. Melero-González Eugenio de Miguel Maite Silva-Díaz Jesús Alejandro Valero Jaimes Ismael González Julio Sánchez Martín Javier Narváez Joan Calvet Ivette Casafont-Solé Jose A Román Ivorra Selene Labrada Arrabal Margarida Vasques Rocha Carlota L Iñiguez María Sagrario Bustabad Reyes Cristina Campos Fernández María Alcalde Villar Antonio Juan Mas Ricardo Blanco on behalf of the ARTESER Project Collaborative Group |
| author_sort | Juan Molina-Collada |
| collection | DOAJ |
| description | Abstract Objectives To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. Results A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. Conclusions The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death. |
| format | Article |
| id | doaj-art-25ae12a1c3b642f58c31fadffdac5bfc |
| institution | Kabale University |
| issn | 1478-6362 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj-art-25ae12a1c3b642f58c31fadffdac5bfc2025-01-12T12:34:01ZengBMCArthritis Research & Therapy1478-63622025-01-0127111010.1186/s13075-024-03468-6Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registryJuan Molina-Collada0Marta Domínguez-Álvaro1Rafael B. Melero-González2Eugenio de Miguel3Maite Silva-Díaz4Jesús Alejandro Valero Jaimes5Ismael González6Julio Sánchez Martín7Javier Narváez8Joan Calvet9Ivette Casafont-Solé10Jose A Román Ivorra11Selene Labrada Arrabal12Margarida Vasques Rocha13Carlota L Iñiguez14María Sagrario Bustabad Reyes15Cristina Campos Fernández16María Alcalde Villar17Antonio Juan Mas18Ricardo Blanco19on behalf of the ARTESER Project Collaborative GroupDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)Research Unit, Sociedad Española de ReumatologíaRheumatology Department, Complexo Hospitalario Universitario de OurenseRheumatology Department, Hospital Universitario La PazRheumatology Department, Complejo Hospitalario Universitario de A CoruñaRheumatology Department, Hospital Universitario DonostiRheumatology Department, Hospital Universitario de LeónRheumatology Department, Hospital Universitario Marqués de Valdecilla. IDIVAL Immunopathology groupRheumatology Department, Hospital Universitari Bellvitge. Hospitalet de LlobregatRheumatology Department, Parc Taulí Hospital Universitari. Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA) (UAB)Rheumatology Department, Hospital Universitari Germans Trias i PujolRheumatology Department, Hospital Universitari i Politècnic La FeRheumatology Department, Hospital del MarRheumatology Department, Hospital Universitario ArabaRheumatology, Hospital Universitario Lucus AugustiRheumatology Department, Hospital Universitario de CanariasRheumatology, Consorci Hospital General Universitari de ValènciaRheumatology Department, Hospital Universitario Severo Ochoa LeganésRheumatology Department, Hospital Universitari Son LlàtzerRheumatology Department, Hospital Universitario Marqués de Valdecilla. IDIVAL Immunopathology groupAbstract Objectives To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. Results A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. Conclusions The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.https://doi.org/10.1186/s13075-024-03468-6MortalitySurvivalGiant cell arteritisVasculitis |
| spellingShingle | Juan Molina-Collada Marta Domínguez-Álvaro Rafael B. Melero-González Eugenio de Miguel Maite Silva-Díaz Jesús Alejandro Valero Jaimes Ismael González Julio Sánchez Martín Javier Narváez Joan Calvet Ivette Casafont-Solé Jose A Román Ivorra Selene Labrada Arrabal Margarida Vasques Rocha Carlota L Iñiguez María Sagrario Bustabad Reyes Cristina Campos Fernández María Alcalde Villar Antonio Juan Mas Ricardo Blanco on behalf of the ARTESER Project Collaborative Group Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry Arthritis Research & Therapy Mortality Survival Giant cell arteritis Vasculitis |
| title | Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry |
| title_full | Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry |
| title_fullStr | Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry |
| title_full_unstemmed | Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry |
| title_short | Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry |
| title_sort | mortality in patients with giant cell arteritis in spain results from the arteser registry |
| topic | Mortality Survival Giant cell arteritis Vasculitis |
| url | https://doi.org/10.1186/s13075-024-03468-6 |
| work_keys_str_mv | AT juanmolinacollada mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT martadominguezalvaro mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT rafaelbmelerogonzalez mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT eugeniodemiguel mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT maitesilvadiaz mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT jesusalejandrovalerojaimes mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT ismaelgonzalez mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT juliosanchezmartin mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT javiernarvaez mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT joancalvet mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT ivettecasafontsole mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT josearomanivorra mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT selenelabradaarrabal mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT margaridavasquesrocha mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT carlotaliniguez mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT mariasagrariobustabadreyes mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT cristinacamposfernandez mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT mariaalcaldevillar mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT antoniojuanmas mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT ricardoblanco mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry AT onbehalfofthearteserprojectcollaborativegroup mortalityinpatientswithgiantcellarteritisinspainresultsfromthearteserregistry |