Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

ObjectivesThe purpose of this study was to investigate the effect of intestinal dysbiosis on the bioavailability of voriconazole and to explore any underlying mechanisms.MethodSprague-Dawley rats were randomly divided into two groups: a normal control group and a ceftriaxone-associated dysbiotic gro...

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Bibliographic Details
Main Authors:	Xiaokang Wang, Chunxiao Ye, Xixiao Yang, Maoxun Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	intestinal bacteria ceftriaxone voriconazole bioavailability P-glycoprotein
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1522271/full
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