Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study
The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α2B-, β1-, and β2-adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2010/458410 |
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| author | Kristina Bengtsson Boström Jan Hedner Ludger Grote Olle Melander Fredrik von Wowern Lennart Råstam Leif Groop Ulf Lindblad |
| author_facet | Kristina Bengtsson Boström Jan Hedner Ludger Grote Olle Melander Fredrik von Wowern Lennart Råstam Leif Groop Ulf Lindblad |
| author_sort | Kristina Bengtsson Boström |
| collection | DOAJ |
| description | The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α2B-, β1-, and β2-adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β1-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02–4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95% CI 1.4–21.2). |
| format | Article |
| id | doaj-art-25aa2e4e5f6a48b0bdb17b6ce59461d8 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-25aa2e4e5f6a48b0bdb17b6ce59461d82025-08-20T03:54:52ZengWileyInternational Journal of Hypertension2090-03922010-01-01201010.4061/2010/458410458410Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep StudyKristina Bengtsson Boström0Jan Hedner1Ludger Grote2Olle Melander3Fredrik von Wowern4Lennart Råstam5Leif Groop6Ulf Lindblad7R&D Centre Skaraborg Primary Care, Storgatan 18, 541 30 Skövde, SwedenSleep Laboratory, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenSleep Laboratory, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDepartment of Clinical Sciences, Diabetes and Endocrinology, Malmö University Hospital, Lund University, 20502 Malmö, SwedenDepartment of Clinical Sciences, Diabetes and Endocrinology, Malmö University Hospital, Lund University, 20502 Malmö, SwedenDepartment of Clinical Sciences, Community Medicine, Malmö University Hospital, Lund University, 20502 Malmö, SwedenDepartment of Clinical Sciences, Diabetes and Endocrinology, Malmö University Hospital, Lund University, 20502 Malmö, SwedenDepartment of Clinical Sciences, Community Medicine, Malmö University Hospital, Lund University, 20502 Malmö, SwedenThe sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α2B-, β1-, and β2-adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β1-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02–4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95% CI 1.4–21.2).http://dx.doi.org/10.4061/2010/458410 |
| spellingShingle | Kristina Bengtsson Boström Jan Hedner Ludger Grote Olle Melander Fredrik von Wowern Lennart Råstam Leif Groop Ulf Lindblad Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study International Journal of Hypertension |
| title | Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study |
| title_full | Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study |
| title_fullStr | Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study |
| title_full_unstemmed | Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study |
| title_short | Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study |
| title_sort | polymorphisms in α and β adrenergic receptor genes hypertension and obstructive sleep apnea the skaraborg sleep study |
| url | http://dx.doi.org/10.4061/2010/458410 |
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