Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro
BACKGROUND: Macrolide antibiotics such as erythromycin and roxithromycin (RXM) have an anti-inflammatory effect that may account for their clinical benefit in the treatment of chronic airway inflammatory diseases. However, the precise mechanism of this anti-inflammatory effect is not well understood...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09629350400008810 |
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| _version_ | 1832566936637014016 |
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| author | Ken-Ichi Kanai Kazuhito Asano Tadashi Hisamitsu Harumi Suzaki |
| author_facet | Ken-Ichi Kanai Kazuhito Asano Tadashi Hisamitsu Harumi Suzaki |
| author_sort | Ken-Ichi Kanai |
| collection | DOAJ |
| description | BACKGROUND: Macrolide antibiotics such as erythromycin and roxithromycin (RXM) have an anti-inflammatory effect that may account for their clinical benefit in the treatment of chronic airway inflammatory diseases. However, the precise mechanism of this anti-inflammatory effect is not well understood. |
| format | Article |
| id | doaj-art-25a2470a99cd4e699cf90ee855467054 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-25a2470a99cd4e699cf90ee8554670542025-02-03T01:02:43ZengWileyMediators of Inflammation0962-93511466-18612004-01-01135-631331910.1080/09629350400008810Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitroKen-Ichi Kanai0Kazuhito Asano1Tadashi Hisamitsu2Harumi Suzaki3Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanBACKGROUND: Macrolide antibiotics such as erythromycin and roxithromycin (RXM) have an anti-inflammatory effect that may account for their clinical benefit in the treatment of chronic airway inflammatory diseases. However, the precise mechanism of this anti-inflammatory effect is not well understood.http://dx.doi.org/10.1080/09629350400008810Macrolide antibioticRoxithromycinNeutrophilMatrix metalloproteinase-9Suppression. |
| spellingShingle | Ken-Ichi Kanai Kazuhito Asano Tadashi Hisamitsu Harumi Suzaki Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro Mediators of Inflammation Macrolide antibiotic Roxithromycin Neutrophil Matrix metalloproteinase-9 Suppression. |
| title | Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro |
| title_full | Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro |
| title_fullStr | Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro |
| title_full_unstemmed | Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro |
| title_short | Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro |
| title_sort | suppression of matrix metalloproteinase 9 production from neutrophils by a macrolide antibiotic roxithromycin in vitro |
| topic | Macrolide antibiotic Roxithromycin Neutrophil Matrix metalloproteinase-9 Suppression. |
| url | http://dx.doi.org/10.1080/09629350400008810 |
| work_keys_str_mv | AT kenichikanai suppressionofmatrixmetalloproteinase9productionfromneutrophilsbyamacrolideantibioticroxithromycininvitro AT kazuhitoasano suppressionofmatrixmetalloproteinase9productionfromneutrophilsbyamacrolideantibioticroxithromycininvitro AT tadashihisamitsu suppressionofmatrixmetalloproteinase9productionfromneutrophilsbyamacrolideantibioticroxithromycininvitro AT harumisuzaki suppressionofmatrixmetalloproteinase9productionfromneutrophilsbyamacrolideantibioticroxithromycininvitro |