Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement
Abstract Background ANCA-associated vasculitis is a systemic autoimmune disease involving small- and medium-sized blood vessels. Eosinophilic granulomatosis with polyangiitis (EGPA, previously Churg Strauss Syndrome) is the least common form in childhood with few cases reported. We present two uniqu...
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2025-06-01
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| Series: | Pediatric Rheumatology Online Journal |
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| Online Access: | https://doi.org/10.1186/s12969-025-01115-1 |
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| author | Evangelia Constantine Adam M. Bartholomeo Inna Powers Jerimiah L. Lysinger Pia J. Hauk Jordan Abbott Heather H. de Keyser Nicholas J. Gilman Csaba Galambos Angus Toland Nicholas Willard Jason Weinman David Mong Clara Lin Jessica L. Bloom |
| author_facet | Evangelia Constantine Adam M. Bartholomeo Inna Powers Jerimiah L. Lysinger Pia J. Hauk Jordan Abbott Heather H. de Keyser Nicholas J. Gilman Csaba Galambos Angus Toland Nicholas Willard Jason Weinman David Mong Clara Lin Jessica L. Bloom |
| author_sort | Evangelia Constantine |
| collection | DOAJ |
| description | Abstract Background ANCA-associated vasculitis is a systemic autoimmune disease involving small- and medium-sized blood vessels. Eosinophilic granulomatosis with polyangiitis (EGPA, previously Churg Strauss Syndrome) is the least common form in childhood with few cases reported. We present two unique pediatric cases, both of which were treated with anti-interleukin-5 therapy. Case presentation Case one is a 13-year-old male with asthma and allergies who presented with one month of cough and periorbital edema and subsequently developed submandibular swelling. Evaluation identified chronic sinusitis, weight loss, positive c-ANCA and anti-MPO IgG antibodies, peripheral blood eosinophilia, pulmonary eosinophilia, tracheal and pulmonary nodules, and eosinophilic infiltration of the submandibular salivary gland with granulomas and fibrosis fitting a diagnosis of EGPA. He improved with glucocorticoids and mepolizumab with a significant partial response, and eventually switched to benralizumab and mycophenolate mofetil with complete response. Case two presented at 19-months-old in acute respiratory distress with a history of reactive airway disease. EGPA diagnosis was confirmed on lung biopsy (eosinophilic capillaritis and interstitial expansion of eosinophils) in the setting of anti-MPO and p-ANCA positivity. He has done very well on mepolizumab for three years. Conclusions To our knowledge, this is the first reported case of submandibular salivary gland infiltrate in a child with EGPA and the youngest successfully treated patient with EGPA reported in the literature. These cases demonstrate the variation in age and disease manifestations seen in children with EGPA as well as positive responses to anti-interleukin-5 therapy. Children with EGPA may present with common or unusual complaints and require astute recognition to avoid delays in diagnosis and long-term damage. |
| format | Article |
| id | doaj-art-25a20519c3964dd1b4cdfd45ef948b25 |
| institution | OA Journals |
| issn | 1546-0096 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj-art-25a20519c3964dd1b4cdfd45ef948b252025-08-20T02:30:45ZengBMCPediatric Rheumatology Online Journal1546-00962025-06-0123111010.1186/s12969-025-01115-1Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvementEvangelia Constantine0Adam M. Bartholomeo1Inna Powers2Jerimiah L. Lysinger3Pia J. Hauk4Jordan Abbott5Heather H. de Keyser6Nicholas J. Gilman7Csaba Galambos8Angus Toland9Nicholas Willard10Jason Weinman11David Mong12Clara Lin13Jessica L. Bloom14School of Medicine, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Rheumatology, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Rheumatology, University of Iowa Carver College of MedicinePediatric Pulmonology, Billings ClinicDepartment of Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Pulmonary and Sleep Medicine, University of Colorado Anschutz Medical CampusSchool of Medicine, University of Colorado Anschutz Medical CampusDepartment of Pathology and Laboratory Services, University of Colorado Anschutz Medical CampusDepartment of Pathology and Laboratory Services, University of Colorado Anschutz Medical CampusDepartment of Pathology and Laboratory Services, University of Colorado Anschutz Medical CampusDepartment of Radiology, University of Colorado Anschutz Medical CampusDepartment of Radiology, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Rheumatology, University of Colorado Anschutz Medical CampusDepartment of Pediatrics, Section of Rheumatology, University of Colorado Anschutz Medical CampusAbstract Background ANCA-associated vasculitis is a systemic autoimmune disease involving small- and medium-sized blood vessels. Eosinophilic granulomatosis with polyangiitis (EGPA, previously Churg Strauss Syndrome) is the least common form in childhood with few cases reported. We present two unique pediatric cases, both of which were treated with anti-interleukin-5 therapy. Case presentation Case one is a 13-year-old male with asthma and allergies who presented with one month of cough and periorbital edema and subsequently developed submandibular swelling. Evaluation identified chronic sinusitis, weight loss, positive c-ANCA and anti-MPO IgG antibodies, peripheral blood eosinophilia, pulmonary eosinophilia, tracheal and pulmonary nodules, and eosinophilic infiltration of the submandibular salivary gland with granulomas and fibrosis fitting a diagnosis of EGPA. He improved with glucocorticoids and mepolizumab with a significant partial response, and eventually switched to benralizumab and mycophenolate mofetil with complete response. Case two presented at 19-months-old in acute respiratory distress with a history of reactive airway disease. EGPA diagnosis was confirmed on lung biopsy (eosinophilic capillaritis and interstitial expansion of eosinophils) in the setting of anti-MPO and p-ANCA positivity. He has done very well on mepolizumab for three years. Conclusions To our knowledge, this is the first reported case of submandibular salivary gland infiltrate in a child with EGPA and the youngest successfully treated patient with EGPA reported in the literature. These cases demonstrate the variation in age and disease manifestations seen in children with EGPA as well as positive responses to anti-interleukin-5 therapy. Children with EGPA may present with common or unusual complaints and require astute recognition to avoid delays in diagnosis and long-term damage.https://doi.org/10.1186/s12969-025-01115-1Eosinophilic granulomatosis with polyangiitisEGPAChurg StraussANCA-associated vasculitisBenralizumabMepolizumab |
| spellingShingle | Evangelia Constantine Adam M. Bartholomeo Inna Powers Jerimiah L. Lysinger Pia J. Hauk Jordan Abbott Heather H. de Keyser Nicholas J. Gilman Csaba Galambos Angus Toland Nicholas Willard Jason Weinman David Mong Clara Lin Jessica L. Bloom Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement Pediatric Rheumatology Online Journal Eosinophilic granulomatosis with polyangiitis EGPA Churg Strauss ANCA-associated vasculitis Benralizumab Mepolizumab |
| title | Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement |
| title_full | Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement |
| title_fullStr | Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement |
| title_full_unstemmed | Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement |
| title_short | Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement |
| title_sort | two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti interleukin 5 therapy infantile onset and submandibular salivary gland involvement |
| topic | Eosinophilic granulomatosis with polyangiitis EGPA Churg Strauss ANCA-associated vasculitis Benralizumab Mepolizumab |
| url | https://doi.org/10.1186/s12969-025-01115-1 |
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