Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review
Abstract Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest in past decades due to their potential to repair and regenerate damaged tissues. Many clinical trial...
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| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-04029-y |
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| author | Jipeng Li Mengting Wu Lijie He |
| author_facet | Jipeng Li Mengting Wu Lijie He |
| author_sort | Jipeng Li |
| collection | DOAJ |
| description | Abstract Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest in past decades due to their potential to repair and regenerate damaged tissues. Many clinical trials have highlighted the safety and effectiveness of kidney disease with this novel cell therapy. MSC infusion can improve renal function indices such as glomerular filtration rate, urine protein, serum creatinine, and blood urea nitrogen, while inhibiting immune response by increasing regulatory T cells. The therapeutic mechanisms may be primarily attributed to a function combined with immunomodulation, anti-inflammation, anti-fibrosis, promoting angiogenesis, anti-oxidation, anti-apoptosis, or tissue healing produced by cell secretsome. However, CKD is a broad concept due to many pathological etiologies including diabetes, hypertension, heart disease, immunological damage, a family history of renal failure, and so on. Furthermore, the therapeutic efficacy of MSCs may be influenced by different cell sources, injection methods, medication dosage, or homing proportion. As a result, it is timely and essential to access recent advancements in the MSC application on CKD. |
| format | Article |
| id | doaj-art-259f154b910f4e07a96a70335fbd4043 |
| institution | DOAJ |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-259f154b910f4e07a96a70335fbd40432025-08-20T03:05:52ZengBMCBMC Nephrology1471-23692025-03-0126111510.1186/s12882-025-04029-yImmunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature reviewJipeng Li0Mengting Wu1Lijie He2Department of Nephrology, Xijing Hospital, Air Force Medical UniversityDepartment of Nephrology, Xijing Hospital, Air Force Medical UniversityDepartment of Nephrology, Xijing Hospital, Air Force Medical UniversityAbstract Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest in past decades due to their potential to repair and regenerate damaged tissues. Many clinical trials have highlighted the safety and effectiveness of kidney disease with this novel cell therapy. MSC infusion can improve renal function indices such as glomerular filtration rate, urine protein, serum creatinine, and blood urea nitrogen, while inhibiting immune response by increasing regulatory T cells. The therapeutic mechanisms may be primarily attributed to a function combined with immunomodulation, anti-inflammation, anti-fibrosis, promoting angiogenesis, anti-oxidation, anti-apoptosis, or tissue healing produced by cell secretsome. However, CKD is a broad concept due to many pathological etiologies including diabetes, hypertension, heart disease, immunological damage, a family history of renal failure, and so on. Furthermore, the therapeutic efficacy of MSCs may be influenced by different cell sources, injection methods, medication dosage, or homing proportion. As a result, it is timely and essential to access recent advancements in the MSC application on CKD.https://doi.org/10.1186/s12882-025-04029-yMesenchymal stem cellChronic kidney diseaseDiabetic nephropathyLupus nephritisImmunomodulation |
| spellingShingle | Jipeng Li Mengting Wu Lijie He Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review BMC Nephrology Mesenchymal stem cell Chronic kidney disease Diabetic nephropathy Lupus nephritis Immunomodulation |
| title | Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review |
| title_full | Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review |
| title_fullStr | Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review |
| title_full_unstemmed | Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review |
| title_short | Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review |
| title_sort | immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease a literature review |
| topic | Mesenchymal stem cell Chronic kidney disease Diabetic nephropathy Lupus nephritis Immunomodulation |
| url | https://doi.org/10.1186/s12882-025-04029-y |
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