Determination of the De Novo Minimum Selection Concentration of Trimethoprim In Vivo for <i>Escherichia coli</i> Using <i>Galleria mellonella:</i> A Pilot Study

Determination of the De Novo Minimum Selection Concentration of Trimethoprim In Vivo for <i>Escherichia coli</i> Using <i>Galleria mellonella:</i> A Pilot Study

We investigated whether the maximum residual levels of trimethoprim permitted in food (Acceptable Daily Intake—ADI) could select for de novo trimethoprim resistance in <i>Escherichia coli</i> in vivo. We designed chronic infection models of <i>E. coli</i> in <i>Galleria...

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Bibliographic Details
Main Authors: Jaime Knox Macleod, Zina Gestels, Said Abdellati, Thibaut Vanbaelen, Chris Kenyon, Sheeba Santhini Manoharan-Basil
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Microorganisms
Subjects:
<i>Escherichia coli</i>
antimicrobial consumption
AMR
resistance
trimethoprim
minimum selection concentration
Online Access:https://www.mdpi.com/2076-2607/13/1/3
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