Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice
Aegle marmelos has been used traditionally in folk medicine for the treatment of gastrointestinal (GI) disorders. Fermentation using probiotics is well established to positively modulate the GI system. This study investigated the therapeutic potential of probiotic-fermented Aegle marmelos juice for...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | International Journal of Food Science |
| Online Access: | http://dx.doi.org/10.1155/ijfo/5288406 |
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| author | Pritika Sharma Aakriti Garg null Nidhi Vasudha Sharma |
| author_facet | Pritika Sharma Aakriti Garg null Nidhi Vasudha Sharma |
| author_sort | Pritika Sharma |
| collection | DOAJ |
| description | Aegle marmelos has been used traditionally in folk medicine for the treatment of gastrointestinal (GI) disorders. Fermentation using probiotics is well established to positively modulate the GI system. This study investigated the therapeutic potential of probiotic-fermented Aegle marmelos juice for ulcerative colitis (UC), using a mouse model. UC was induced in mice with dextran sulphate sodium (DSS), leading to weight loss, increased disease activity, and lowered antioxidant defenses. In contrast, mice treated with probiotic-fermented Aegle marmelos juice showed improved body weight, reduced disease activity index, and mitigated colon damage. Inflammatory biomarkers were decreased, while antioxidant activity increased. High-performance liquid chromatography analysis of the fresh and probiotic-fermented Aegle marmelos juice revealed an increase in potential bioactive compounds compared to its unfermented counterpart. These findings suggest that probiotic-fermented Aegle marmelos juice could be a promising therapeutic option for UC, countering inflammation and displaying antioxidant properties. |
| format | Article |
| id | doaj-art-259d4f39e7594aa89952e5fda8718f7a |
| institution | OA Journals |
| issn | 2314-5765 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Food Science |
| spelling | doaj-art-259d4f39e7594aa89952e5fda8718f7a2025-08-20T02:11:36ZengWileyInternational Journal of Food Science2314-57652025-01-01202510.1155/ijfo/5288406Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos JuicePritika Sharma0Aakriti Garg1null Nidhi2Vasudha Sharma3Department of Food TechnologyDepartment of PharmacologyCentre for Translational and Clinical ResearchDepartment of Food TechnologyAegle marmelos has been used traditionally in folk medicine for the treatment of gastrointestinal (GI) disorders. Fermentation using probiotics is well established to positively modulate the GI system. This study investigated the therapeutic potential of probiotic-fermented Aegle marmelos juice for ulcerative colitis (UC), using a mouse model. UC was induced in mice with dextran sulphate sodium (DSS), leading to weight loss, increased disease activity, and lowered antioxidant defenses. In contrast, mice treated with probiotic-fermented Aegle marmelos juice showed improved body weight, reduced disease activity index, and mitigated colon damage. Inflammatory biomarkers were decreased, while antioxidant activity increased. High-performance liquid chromatography analysis of the fresh and probiotic-fermented Aegle marmelos juice revealed an increase in potential bioactive compounds compared to its unfermented counterpart. These findings suggest that probiotic-fermented Aegle marmelos juice could be a promising therapeutic option for UC, countering inflammation and displaying antioxidant properties.http://dx.doi.org/10.1155/ijfo/5288406 |
| spellingShingle | Pritika Sharma Aakriti Garg null Nidhi Vasudha Sharma Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice International Journal of Food Science |
| title | Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice |
| title_full | Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice |
| title_fullStr | Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice |
| title_full_unstemmed | Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice |
| title_short | Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice |
| title_sort | amelioration of ulcerative colitis in balb c mice by probiotic fermented aegle marmelos juice |
| url | http://dx.doi.org/10.1155/ijfo/5288406 |
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