Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5’-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet ( Craterellus co...
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| Language: | English |
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2022-06-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Black-Trumpet-Craterellus-cornucopioides-L-Pers-Culinary-Mushroom-with-Angiotensin,149914,0,2.html |
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| author | Jelena Radović Aleksandra Leković Ana Tačić Margarita Dodevska Tatjana Stanojković Tijana Marinković Čedomir Jelić Tatjana Kundakovic-Vasović |
| author_facet | Jelena Radović Aleksandra Leković Ana Tačić Margarita Dodevska Tatjana Stanojković Tijana Marinković Čedomir Jelić Tatjana Kundakovic-Vasović |
| author_sort | Jelena Radović |
| collection | DOAJ |
| description | Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5’-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet ( Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5’-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3–155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC 50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet. |
| format | Article |
| id | doaj-art-2597e8857a704a90ae3f86517a3afd5a |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-2597e8857a704a90ae3f86517a3afd5a2025-02-02T16:03:44ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072022-06-0172217118110.31883/pjfns/149914149914Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic ActivityJelena Radović0https://orcid.org/0000-0001-7324-1647Aleksandra Leković1Ana Tačić2https://orcid.org/0000-0003-3119-033XMargarita Dodevska3https://orcid.org/0000-0001-6030-459XTatjana Stanojković4https://orcid.org/0000-0001-9178-9200Tijana Marinković5Čedomir Jelić6Tatjana Kundakovic-Vasović7https://orcid.org/0000-0001-5777-8612Department of Pharmacognosy, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11322 Belgrade, SerbiaDepartment of Pharmacognosy, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11322 Belgrade, SerbiaDepartment of Organic Chemistry, Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, SerbiaInstitute of Public Health of Serbia “Dr Milan Jovanovic Batut”, dr Subotića 5, 11000 Belgrade, SerbiaExperimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 11, 11000 Belgrade, SerbiaInstitute of Public Health Kragujevac, Nikole Pašića 1, 34000 Kragujevac, SerbiaInstitute of Public Health Kragujevac, Nikole Pašića 1, 34000 Kragujevac, SerbiaDepartment of Pharmacognosy, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11322 Belgrade, SerbiaNutritional value and chemical composition, including the content of vitamins, fatty acids, 5’-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet ( Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5’-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3–155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC 50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.http://journal.pan.olsztyn.pl/Black-Trumpet-Craterellus-cornucopioides-L-Pers-Culinary-Mushroom-with-Angiotensin,149914,0,2.htmlcraterellus cornucopioidesβ-glucannutrientsangiotensin converting enzyme inhibitioncytotoxicity |
| spellingShingle | Jelena Radović Aleksandra Leković Ana Tačić Margarita Dodevska Tatjana Stanojković Tijana Marinković Čedomir Jelić Tatjana Kundakovic-Vasović Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity Polish Journal of Food and Nutrition Sciences craterellus cornucopioides β-glucan nutrients angiotensin converting enzyme inhibition cytotoxicity |
| title | Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity |
| title_full | Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity |
| title_fullStr | Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity |
| title_full_unstemmed | Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity |
| title_short | Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity |
| title_sort | black trumpet craterellus cornucopioides l pers culinary mushroom with angiotensin converting enzyme inhibitory and cytotoxic activity |
| topic | craterellus cornucopioides β-glucan nutrients angiotensin converting enzyme inhibition cytotoxicity |
| url | http://journal.pan.olsztyn.pl/Black-Trumpet-Craterellus-cornucopioides-L-Pers-Culinary-Mushroom-with-Angiotensin,149914,0,2.html |
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