Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006
Abstract Background Obesity has been linked to chronic inflammation and insulin resistance and oxidative stress, which are all associated with the pathogenesis of endometriosis (EMs). This study aimed to investigate the associations between the emerging metabolic markers-lipid accumulation product (...
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2025-07-01
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| author | Nan Ma Yingying Hu Yan Xu |
| author_facet | Nan Ma Yingying Hu Yan Xu |
| author_sort | Nan Ma |
| collection | DOAJ |
| description | Abstract Background Obesity has been linked to chronic inflammation and insulin resistance and oxidative stress, which are all associated with the pathogenesis of endometriosis (EMs). This study aimed to investigate the associations between the emerging metabolic markers-lipid accumulation product (LAP) and visceral adiposity index (VAI)-with the EMs. Methods This study utilized data from the National Health and Nutrition Examination Surveys (NHANES) 1999–2006. Weighted univariate and multivariate logistics regression models were conducted to explore the associations between LAP and VAI with EMs, with the results expressed as odds ratios (ORs) and 95% confidence intervals (CIs). Moreover, the subgroup analyses based on age, the history of pregnancy, chronic kidney disease (CKD), and female hormones use were further performed to verify whether theses associations remain robust. Results Totally 5,188 eligible women were included, with a mean age of 37.19 ± 0.18 years. Among them, 359 (6.92%) had EMs. After adjusted all covariates, we observed both highest LAP and VAI are associated with EMs (LAP: OR = 1.56, 95%CI: 1.02–2.39; VAI: OR = 1.54, 95%CI: 1.09–2.18). Subgroup analyses shown that the associations between LAP and VAI with EMs were more significant among women aged ≥ 35 years, with the female hormones use, with the history of pregnancy, and without the history of CKD. Conclusion We observed both high LAP and VAI were associated with EMs among reproductive women in the United States. However, further large-scale, well-designed, prospective cohort studies still need in the future to confirm these findings. |
| format | Article |
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| institution | DOAJ |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-2596e14af2cf478c8eb8562d0516346b2025-08-20T03:04:20ZengBMCBMC Women's Health1472-68742025-07-0125111110.1186/s12905-025-03862-5Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006Nan Ma0Yingying Hu1Yan Xu2Obstetrics and Gynecology Hospital of Fudan UniversityObstetrics and Gynecology Hospital of Fudan UniversityObstetrics and Gynecology Hospital of Fudan UniversityAbstract Background Obesity has been linked to chronic inflammation and insulin resistance and oxidative stress, which are all associated with the pathogenesis of endometriosis (EMs). This study aimed to investigate the associations between the emerging metabolic markers-lipid accumulation product (LAP) and visceral adiposity index (VAI)-with the EMs. Methods This study utilized data from the National Health and Nutrition Examination Surveys (NHANES) 1999–2006. Weighted univariate and multivariate logistics regression models were conducted to explore the associations between LAP and VAI with EMs, with the results expressed as odds ratios (ORs) and 95% confidence intervals (CIs). Moreover, the subgroup analyses based on age, the history of pregnancy, chronic kidney disease (CKD), and female hormones use were further performed to verify whether theses associations remain robust. Results Totally 5,188 eligible women were included, with a mean age of 37.19 ± 0.18 years. Among them, 359 (6.92%) had EMs. After adjusted all covariates, we observed both highest LAP and VAI are associated with EMs (LAP: OR = 1.56, 95%CI: 1.02–2.39; VAI: OR = 1.54, 95%CI: 1.09–2.18). Subgroup analyses shown that the associations between LAP and VAI with EMs were more significant among women aged ≥ 35 years, with the female hormones use, with the history of pregnancy, and without the history of CKD. Conclusion We observed both high LAP and VAI were associated with EMs among reproductive women in the United States. However, further large-scale, well-designed, prospective cohort studies still need in the future to confirm these findings.https://doi.org/10.1186/s12905-025-03862-5Lipid accumulation productVisceral adiposity indexEndometriosisNHANES databaseCross-sectional study |
| spellingShingle | Nan Ma Yingying Hu Yan Xu Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 BMC Women's Health Lipid accumulation product Visceral adiposity index Endometriosis NHANES database Cross-sectional study |
| title | Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 |
| title_full | Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 |
| title_fullStr | Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 |
| title_full_unstemmed | Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 |
| title_short | Association between lipid accumulation product and visceral adiposity index with endometriosis: evidence from NHANES 1999–2006 |
| title_sort | association between lipid accumulation product and visceral adiposity index with endometriosis evidence from nhanes 1999 2006 |
| topic | Lipid accumulation product Visceral adiposity index Endometriosis NHANES database Cross-sectional study |
| url | https://doi.org/10.1186/s12905-025-03862-5 |
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