Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs
In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous i...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0015 |
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| author | Simšič Tilen Planinšek Odon Baumgartner Ana |
| author_facet | Simšič Tilen Planinšek Odon Baumgartner Ana |
| author_sort | Simšič Tilen |
| collection | DOAJ |
| description | In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous initiatives, and regulatory frameworks have been developed to develop more child-friendly dosage forms. In recent years, multiparticulate dosage forms such as mini-tablets, pellets, and granules have gained popularity. However, a major challenge that persists is effectively masking the bitter taste of drugs in such formulations. This review therefore provides a brief overview of the current state of the art in taste masking techniques, with a particular focus on taste masking by film coating. Methods for evaluating the effectiveness of taste masking are also discussed and commented on. Another important issue that arises frequently in this area is achieving sufficient dissolution of poorly water-soluble drugs. Since the simultaneous combination of sufficient dissolution and taste masking is particularly challenging, the second objective of this review is to provide a critical summary of studies dealing with multiparticulate formulations that are tackling both of these issues. |
| format | Article |
| id | doaj-art-258e75fb52a24494897edab4b27756fb |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-258e75fb52a24494897edab4b27756fb2025-02-03T03:49:01ZengSciendoActa Pharmaceutica1846-95582024-06-0174217719910.2478/acph-2024-0015Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugsSimšič Tilen0Planinšek Odon1Baumgartner Ana21Faculty of Pharmacy, University of Ljubljana, 1000Ljubljana, Slovenia1Faculty of Pharmacy, University of Ljubljana, 1000Ljubljana, Slovenia1Faculty of Pharmacy, University of Ljubljana, 1000Ljubljana, SloveniaIn the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous initiatives, and regulatory frameworks have been developed to develop more child-friendly dosage forms. In recent years, multiparticulate dosage forms such as mini-tablets, pellets, and granules have gained popularity. However, a major challenge that persists is effectively masking the bitter taste of drugs in such formulations. This review therefore provides a brief overview of the current state of the art in taste masking techniques, with a particular focus on taste masking by film coating. Methods for evaluating the effectiveness of taste masking are also discussed and commented on. Another important issue that arises frequently in this area is achieving sufficient dissolution of poorly water-soluble drugs. Since the simultaneous combination of sufficient dissolution and taste masking is particularly challenging, the second objective of this review is to provide a critical summary of studies dealing with multiparticulate formulations that are tackling both of these issues.https://doi.org/10.2478/acph-2024-0015multiparticulate dosage formstaste maskingpaediatricfilm coatingsolubility enhancementevaluation methods |
| spellingShingle | Simšič Tilen Planinšek Odon Baumgartner Ana Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs Acta Pharmaceutica multiparticulate dosage forms taste masking paediatric film coating solubility enhancement evaluation methods |
| title | Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| title_full | Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| title_fullStr | Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| title_full_unstemmed | Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| title_short | Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| title_sort | taste masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs |
| topic | multiparticulate dosage forms taste masking paediatric film coating solubility enhancement evaluation methods |
| url | https://doi.org/10.2478/acph-2024-0015 |
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