Phase II trial of intravenous human dental pulp stem cell therapy for Huntington’s disease: a randomized, double-blind, placebo-controlled study

Phase II trial of intravenous human dental pulp stem cell therapy for Huntington’s disease: a randomized, double-blind, placebo-controlled study

Abstract Background Huntington’s disease (HD) is a rare, autosomal dominant neurodegenerative disorder caused by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. It manifests with motor, cognitive, and behavioural impairments, leading to progressive...

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Bibliographic Details
Main Authors: Joyce Macedo Sanches Fernandes, Eduardo Pagani, Cristiane Valverde Wenceslau, Leandro Hideki Ynoue, Luciana Ferrara, Irina Kerkis
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Huntington’s disease
Stem cells
Unified Huntington’s disease rating scale
Online Access:https://doi.org/10.1186/s13287-025-04557-2
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