Nanophotonic-enhanced photoacoustic imaging for brain tumor detection
Abstract Photoacoustic brain imaging (PABI) has emerged as a promising biomedical imaging modality, combining high contrast of optical imaging with deep tissue penetration of ultrasound imaging. This review explores the application of photoacoustic imaging in brain tumor imaging, highlighting the sy...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03204-5 |
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| author | Ali Rizwan Badrinathan Sridharan Jin Hyeong Park Daehun Kim Jean-Claude Vial Kwangseuk Kyhm Hae Gyun Lim |
| author_facet | Ali Rizwan Badrinathan Sridharan Jin Hyeong Park Daehun Kim Jean-Claude Vial Kwangseuk Kyhm Hae Gyun Lim |
| author_sort | Ali Rizwan |
| collection | DOAJ |
| description | Abstract Photoacoustic brain imaging (PABI) has emerged as a promising biomedical imaging modality, combining high contrast of optical imaging with deep tissue penetration of ultrasound imaging. This review explores the application of photoacoustic imaging in brain tumor imaging, highlighting the synergy between nanomaterials and state of the art optical techniques to achieve high-resolution imaging of deeper brain tissues. PABI leverages the photoacoustic effect, where absorbed light energy causes thermoelastic expansion, generating ultrasound waves that are detected and converted into images. This technique enables precise diagnosis, therapy monitoring, and enhanced clinical screening, specifically in the management of complex diseases such as breast cancer, lymphatic disorder, and neurological conditions. Despite integration of photoacoustic agents and ultrasound radiation, providing a comprehensive overview of current methodologies, major obstacles in brain tumor treatment, and future directions for improving diagnostic and therapeutic outcomes. The review underscores the significance of PABI as a robust research tool and medical method, with the potential to revolutionize brain disease diagnosis and treatment. Graphical Abstract |
| format | Article |
| id | doaj-art-25835abb5d0b45269751ca7066b9c61e |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-25835abb5d0b45269751ca7066b9c61e2025-08-20T03:05:49ZengBMCJournal of Nanobiotechnology1477-31552025-03-0123113010.1186/s12951-025-03204-5Nanophotonic-enhanced photoacoustic imaging for brain tumor detectionAli Rizwan0Badrinathan Sridharan1Jin Hyeong Park2Daehun Kim3Jean-Claude Vial4Kwangseuk Kyhm5Hae Gyun Lim6Smart Gym-Based Translational Research Center for Active Senior’S Healthcare, Pukyong National UniversityDepartment of Biomedical Engineering, Pukyong National UniversityDepartment of Biomedical Engineering, Pukyong National UniversityIndusrty 4.0 Convergence Bionics Engineering, Pukyong National UniversityUniversité Grenoble Alpes, CNRS, LIPhyDepartment of Optics & Cogno-Mechatronics Engineering, Pusan National UniversitySmart Gym-Based Translational Research Center for Active Senior’S Healthcare, Pukyong National UniversityAbstract Photoacoustic brain imaging (PABI) has emerged as a promising biomedical imaging modality, combining high contrast of optical imaging with deep tissue penetration of ultrasound imaging. This review explores the application of photoacoustic imaging in brain tumor imaging, highlighting the synergy between nanomaterials and state of the art optical techniques to achieve high-resolution imaging of deeper brain tissues. PABI leverages the photoacoustic effect, where absorbed light energy causes thermoelastic expansion, generating ultrasound waves that are detected and converted into images. This technique enables precise diagnosis, therapy monitoring, and enhanced clinical screening, specifically in the management of complex diseases such as breast cancer, lymphatic disorder, and neurological conditions. Despite integration of photoacoustic agents and ultrasound radiation, providing a comprehensive overview of current methodologies, major obstacles in brain tumor treatment, and future directions for improving diagnostic and therapeutic outcomes. The review underscores the significance of PABI as a robust research tool and medical method, with the potential to revolutionize brain disease diagnosis and treatment. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03204-5NanophotonicsUltrasoundPhotoacoustic brain imagingBlood–brain barrier |
| spellingShingle | Ali Rizwan Badrinathan Sridharan Jin Hyeong Park Daehun Kim Jean-Claude Vial Kwangseuk Kyhm Hae Gyun Lim Nanophotonic-enhanced photoacoustic imaging for brain tumor detection Journal of Nanobiotechnology Nanophotonics Ultrasound Photoacoustic brain imaging Blood–brain barrier |
| title | Nanophotonic-enhanced photoacoustic imaging for brain tumor detection |
| title_full | Nanophotonic-enhanced photoacoustic imaging for brain tumor detection |
| title_fullStr | Nanophotonic-enhanced photoacoustic imaging for brain tumor detection |
| title_full_unstemmed | Nanophotonic-enhanced photoacoustic imaging for brain tumor detection |
| title_short | Nanophotonic-enhanced photoacoustic imaging for brain tumor detection |
| title_sort | nanophotonic enhanced photoacoustic imaging for brain tumor detection |
| topic | Nanophotonics Ultrasound Photoacoustic brain imaging Blood–brain barrier |
| url | https://doi.org/10.1186/s12951-025-03204-5 |
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