A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests

A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests

<b>Objectives</b>: Ultrafiltration (UF) is widely accepted as a method for assessing the plasma protein binding (PPB) of drugs. However, it is vulnerable to non-specific binding (NSB) to the device, which can result in inaccuracies. This study presents a straightforward, high-throughput...

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Bibliographic Details
Main Authors: Sang Ho Jeon, Min Chang Kim, Haejun Lee, Ju-Hee Oh, Hyun Seo Kim, Heawon Lee, Taehoon Park, Young-Joo Lee
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceutics
Subjects:
plasma protein binding
ultrafiltration
non-specific binding
Online Access:https://www.mdpi.com/1999-4923/17/2/273
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