Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies
Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/11/490 |
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| author | Pasquale Niscola Valentina Gianfelici Gianfranco Catalano Marco Giovannini Carla Mazzone Nelida Ines Noguera Paolo de Fabritiis |
| author_facet | Pasquale Niscola Valentina Gianfelici Gianfranco Catalano Marco Giovannini Carla Mazzone Nelida Ines Noguera Paolo de Fabritiis |
| author_sort | Pasquale Niscola |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults. |
| format | Article |
| id | doaj-art-258041d01a624da3b0a4ff2280cfb46c |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-258041d01a624da3b0a4ff2280cfb46c2025-08-20T02:28:08ZengMDPI AGCurrent Oncology1198-00521718-77292024-10-0131116632665810.3390/curroncol31110490Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted TherapiesPasquale Niscola0Valentina Gianfelici1Gianfranco Catalano2Marco Giovannini3Carla Mazzone4Nelida Ines Noguera5Paolo de Fabritiis6Hematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, ItalyHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, ItalyHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyHematology Unit, S. Eugenio Hospital (ASL Roma 2), 00144 Rome, ItalyAcute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults.https://www.mdpi.com/1718-7729/31/11/490genomic profilingtargeted therapieshypomethylating agentsvenetoclax-based combinationsintensive chemotherapytransplantation clinical trials |
| spellingShingle | Pasquale Niscola Valentina Gianfelici Gianfranco Catalano Marco Giovannini Carla Mazzone Nelida Ines Noguera Paolo de Fabritiis Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies Current Oncology genomic profiling targeted therapies hypomethylating agents venetoclax-based combinations intensive chemotherapy transplantation clinical trials |
| title | Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies |
| title_full | Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies |
| title_fullStr | Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies |
| title_full_unstemmed | Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies |
| title_short | Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies |
| title_sort | acute myeloid leukemia in older patients from new biological insights to targeted therapies |
| topic | genomic profiling targeted therapies hypomethylating agents venetoclax-based combinations intensive chemotherapy transplantation clinical trials |
| url | https://www.mdpi.com/1718-7729/31/11/490 |
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