Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt
Abstract Psoriatic arthritis (PsA) is a very heterogeneous disease with significant impact on health-related quality-of-life (HRQoL). Our objective was to assess and identify predictors of HRQoL in a 3-year follow-up period among PsA patients. Patients with PsA included in the Rheumatic Diseases Por...
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Nature Portfolio
2025-08-01
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| author | Helena Santos Ana Rita Henriques Helena Canhão Pedro M. Machado Fernando M. Pimentel-Santos Cândida Silva Bárbara Lobão José Miguel Bernardes Carlos Gomes Vanessa Fraga Catarina Abreu Hugo Parente Catarina Dantas Soares Mariana Luís Elsa Vieira-Sousa Maura Couto Anabela Barcelos Graça Sequeira Teresa Nóvoa Patricia Nero Filipe Barcelos Ana Maria Rodrigues |
| author_facet | Helena Santos Ana Rita Henriques Helena Canhão Pedro M. Machado Fernando M. Pimentel-Santos Cândida Silva Bárbara Lobão José Miguel Bernardes Carlos Gomes Vanessa Fraga Catarina Abreu Hugo Parente Catarina Dantas Soares Mariana Luís Elsa Vieira-Sousa Maura Couto Anabela Barcelos Graça Sequeira Teresa Nóvoa Patricia Nero Filipe Barcelos Ana Maria Rodrigues |
| author_sort | Helena Santos |
| collection | DOAJ |
| description | Abstract Psoriatic arthritis (PsA) is a very heterogeneous disease with significant impact on health-related quality-of-life (HRQoL). Our objective was to assess and identify predictors of HRQoL in a 3-year follow-up period among PsA patients. Patients with PsA included in the Rheumatic Diseases Portuguese Register (Reuma.pt), with HRQoL data measured by the EuroQoL five Dimensions (EQ-5D) with at least two evaluations throughout a 3-year period, were analysed. Statistics included t-tests, logit and linear mixed models and univariable and multivariable linear regression. PsA patients’ (n = 342) mean age 51.0 (12.2) years, 48.5% being female, mean disease duration 11.8 (9.3) years with a follow-up period of 3-years had a mean EQ-5D of 0.53 (0.28), 0.59 (0.29), and 0.58 (0.28) at baseline, 1-year and 3-year evaluations, respectively. During the follow-up period, EQ-5D score and EQ VAS, significantly improved at both time-point assessments, compared to baseline. Poorer HRQoL was significantly associated with older age (β=-0.004; p-value = 0.008), female sex (β=-0.092; p-value = 0.01), non-employment (β=-0.112; p-value = 0.018), higher disease activity (β=-0.005; p-value < 0.001), prior exposure of three or more biologics at baseline and switching of biologic therapy during the study follow-up [(β=-0.182; p-value = 0.04); (β=-0.150; p-value = 0.002), respectively]. Our study provides important insights into the long-term predictors of HRQoL in PsA patients, highlighting the influence of sociodemographic factors, disease activity and therapeutic approach (prior use and switch/cycle of biologic therapies) on HRQoL. |
| format | Article |
| id | doaj-art-257e16b40bc54bf58fff8b426e682227 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
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| spelling | doaj-art-257e16b40bc54bf58fff8b426e6822272025-08-20T03:05:21ZengNature PortfolioScientific Reports2045-23222025-08-0115111210.1038/s41598-025-14790-7Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.ptHelena Santos0Ana Rita Henriques1Helena Canhão2Pedro M. Machado3Fernando M. Pimentel-Santos4Cândida Silva5Bárbara Lobão6José Miguel Bernardes7Carlos Gomes8Vanessa Fraga9Catarina Abreu10Hugo Parente11Catarina Dantas Soares12Mariana Luís13Elsa Vieira-Sousa14Maura Couto15Anabela Barcelos16Graça Sequeira17Teresa Nóvoa18Patricia Nero19Filipe Barcelos20Ana Maria Rodrigues21EpiDoc Unit/Comprehensive Health Research Center -Nova Medical School, Universidade Nova de LisboaEpiDoc Unit/Comprehensive Health Research Center -Nova Medical School, Universidade Nova de LisboaEpiDoc Unit/Comprehensive Health Research Center -Nova Medical School, Universidade Nova de LisboaCentre for Rheumatology, Department of Neuromuscular Diseases, University College of LondonRheumatic Diseases Lab - Nova Medical School, NMS Research – iNOVA4Health, Universidade Nova de LisboaInstituto Português de ReumatologiaInstituto Português de ReumatologiaRheumatology Department, Unidade de Saúde Local de S. JoãoRheumatology Department, Unidade de Saúde Local de S. JoãoRheumatology Department, Hospital Garcia de OrtaRheumatology Department, Hospital Garcia de OrtaRheumatology Department, Unidade Local de Saúde do Alto MinhoRheumatology Department, Unidade Local de Saúde do Alto MinhoRheumatology Department, Centro Hospitalar e Universitário de CoimbraRheumatology and Osteometabolic Diseases Department, Hospital de Santa Maria, CHULNRheumatology Department, Unidade Local Saude Viseu-Dão LafõesRheumatology Department, Centro Hospitalar do Baixo VougaRheumatology Department, Centro Hospitalar do Algarve – Unidade de FaroRheumatology Department, Hospital do Divino Espirito SantoRheumatology Department, Hospital CUF DescobertasInstituto Português de ReumatologiaEpiDoc Unit/Comprehensive Health Research Center -Nova Medical School, Universidade Nova de LisboaAbstract Psoriatic arthritis (PsA) is a very heterogeneous disease with significant impact on health-related quality-of-life (HRQoL). Our objective was to assess and identify predictors of HRQoL in a 3-year follow-up period among PsA patients. Patients with PsA included in the Rheumatic Diseases Portuguese Register (Reuma.pt), with HRQoL data measured by the EuroQoL five Dimensions (EQ-5D) with at least two evaluations throughout a 3-year period, were analysed. Statistics included t-tests, logit and linear mixed models and univariable and multivariable linear regression. PsA patients’ (n = 342) mean age 51.0 (12.2) years, 48.5% being female, mean disease duration 11.8 (9.3) years with a follow-up period of 3-years had a mean EQ-5D of 0.53 (0.28), 0.59 (0.29), and 0.58 (0.28) at baseline, 1-year and 3-year evaluations, respectively. During the follow-up period, EQ-5D score and EQ VAS, significantly improved at both time-point assessments, compared to baseline. Poorer HRQoL was significantly associated with older age (β=-0.004; p-value = 0.008), female sex (β=-0.092; p-value = 0.01), non-employment (β=-0.112; p-value = 0.018), higher disease activity (β=-0.005; p-value < 0.001), prior exposure of three or more biologics at baseline and switching of biologic therapy during the study follow-up [(β=-0.182; p-value = 0.04); (β=-0.150; p-value = 0.002), respectively]. Our study provides important insights into the long-term predictors of HRQoL in PsA patients, highlighting the influence of sociodemographic factors, disease activity and therapeutic approach (prior use and switch/cycle of biologic therapies) on HRQoL.https://doi.org/10.1038/s41598-025-14790-7Quality of lifePsoriatic arthritisLongitudinal studiesPatient reported outcome measures determinants of healthBiological therapy. |
| spellingShingle | Helena Santos Ana Rita Henriques Helena Canhão Pedro M. Machado Fernando M. Pimentel-Santos Cândida Silva Bárbara Lobão José Miguel Bernardes Carlos Gomes Vanessa Fraga Catarina Abreu Hugo Parente Catarina Dantas Soares Mariana Luís Elsa Vieira-Sousa Maura Couto Anabela Barcelos Graça Sequeira Teresa Nóvoa Patricia Nero Filipe Barcelos Ana Maria Rodrigues Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt Scientific Reports Quality of life Psoriatic arthritis Longitudinal studies Patient reported outcome measures determinants of health Biological therapy. |
| title | Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt |
| title_full | Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt |
| title_fullStr | Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt |
| title_full_unstemmed | Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt |
| title_short | Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt |
| title_sort | sociodemographic factors and biologic therapy exposure impacting health related quality of life in psoriatic arthritis findings from a nationwide registry reuma pt |
| topic | Quality of life Psoriatic arthritis Longitudinal studies Patient reported outcome measures determinants of health Biological therapy. |
| url | https://doi.org/10.1038/s41598-025-14790-7 |
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