Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review
Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-02-01
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| Series: | Case Reports in Gastroenterology |
| Online Access: | https://karger.com/article/doi/10.1159/000543679 |
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| _version_ | 1849321673912745984 |
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| author | Atul Shrestha Sarah Elliott Joshua Haron Abasszade Kyle Wu Thomas Worland Ian Simpson Anouk Dev |
| author_facet | Atul Shrestha Sarah Elliott Joshua Haron Abasszade Kyle Wu Thomas Worland Ian Simpson Anouk Dev |
| author_sort | Atul Shrestha |
| collection | DOAJ |
| description |
Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper. Case Presentation: We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper “wellness shots” leading to a significant drug-induced liver injury. Conclusion: This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper’s hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use. |
| format | Article |
| id | doaj-art-25780d7fb93c4fc9ad8f765e0d5d6b0b |
| institution | Kabale University |
| issn | 1662-0631 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj-art-25780d7fb93c4fc9ad8f765e0d5d6b0b2025-08-20T03:49:41ZengKarger PublishersCase Reports in Gastroenterology1662-06312025-02-011919610610.1159/000543679Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and ReviewAtul ShresthaSarah ElliottJoshua Haron AbasszadeKyle WuThomas WorlandIan SimpsonAnouk Dev Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper. Case Presentation: We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper “wellness shots” leading to a significant drug-induced liver injury. Conclusion: This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper’s hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use. https://karger.com/article/doi/10.1159/000543679 |
| spellingShingle | Atul Shrestha Sarah Elliott Joshua Haron Abasszade Kyle Wu Thomas Worland Ian Simpson Anouk Dev Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review Case Reports in Gastroenterology |
| title | Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| title_full | Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| title_fullStr | Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| title_full_unstemmed | Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| title_short | Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| title_sort | drug induced liver injury associated with turmeric and piperine a case and review |
| url | https://karger.com/article/doi/10.1159/000543679 |
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