MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN
Aim: to establish prognostic morphological criteria of complicated clinical course of Crohn’s disease in children. Patients and methods: morphometric and histological characteristics of the mucous membrane of the large intestine were studied in 27 patients with colitis form of Crohn’s disease on the...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2013-09-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/291 |
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| author | E. N. Fedulova E. A. Zhukova O. A. Tutina T. A. Kuznetsova O. V. Shumilova O. V. Fedorova |
| author_facet | E. N. Fedulova E. A. Zhukova O. A. Tutina T. A. Kuznetsova O. V. Shumilova O. V. Fedorova |
| author_sort | E. N. Fedulova |
| collection | DOAJ |
| description | Aim: to establish prognostic morphological criteria of complicated clinical course of Crohn’s disease in children. Patients and methods: morphometric and histological characteristics of the mucous membrane of the large intestine were studied in 27 patients with colitis form of Crohn’s disease on their first admission to a hospital. Results: the most informative predictive morphological criteria for unfavorable prognosis were the following: predominance of the non-active macrophages tending to aggregation in the lamina propria mucosae; destructive vasculitis; increase in the number of fibroblastic cells with the prevalence of the young forms. Non-active macrophages and immature fibroblasts under hypoxia conditions, associated with necrotizing vasculitits, are the factors which contribute to development of fibrosis in the mucous membrane of the large intestine. Conclusitons: unfavorable prognostic morphological criteria of Crohn’s disease were determined. These criteria allow using more aggressive treatment management («top-down» scheme) with early administration of steroid, cytostatic and anti-cytokine drugs in order to prevent the development of complications due to intestinal fibrosis. |
| format | Article |
| id | doaj-art-25766a3b7c0449d2bf888b796eeb04f2 |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-25766a3b7c0449d2bf888b796eeb04f22025-08-20T03:21:14Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-09-0112510811110.15690/vsp.v12i5.808291MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDRENE. N. Fedulova0E. A. Zhukova1O. A. Tutina2T. A. Kuznetsova3O. V. Shumilova4O. V. Fedorova5Nizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyNizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyNizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyNizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyNizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyNizhny Novgorod Scientific Research Institute of Pediatric GastroenterologyAim: to establish prognostic morphological criteria of complicated clinical course of Crohn’s disease in children. Patients and methods: morphometric and histological characteristics of the mucous membrane of the large intestine were studied in 27 patients with colitis form of Crohn’s disease on their first admission to a hospital. Results: the most informative predictive morphological criteria for unfavorable prognosis were the following: predominance of the non-active macrophages tending to aggregation in the lamina propria mucosae; destructive vasculitis; increase in the number of fibroblastic cells with the prevalence of the young forms. Non-active macrophages and immature fibroblasts under hypoxia conditions, associated with necrotizing vasculitits, are the factors which contribute to development of fibrosis in the mucous membrane of the large intestine. Conclusitons: unfavorable prognostic morphological criteria of Crohn’s disease were determined. These criteria allow using more aggressive treatment management («top-down» scheme) with early administration of steroid, cytostatic and anti-cytokine drugs in order to prevent the development of complications due to intestinal fibrosis.https://vsp.spr-journal.ru/jour/article/view/291crohn’s diseasechildrenfibroblasts |
| spellingShingle | E. N. Fedulova E. A. Zhukova O. A. Tutina T. A. Kuznetsova O. V. Shumilova O. V. Fedorova MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN Вопросы современной педиатрии crohn’s disease children fibroblasts |
| title | MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN |
| title_full | MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN |
| title_fullStr | MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN |
| title_full_unstemmed | MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN |
| title_short | MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN |
| title_sort | morphological criteria for prediction of severity of crohn s disease clinical course in children |
| topic | crohn’s disease children fibroblasts |
| url | https://vsp.spr-journal.ru/jour/article/view/291 |
| work_keys_str_mv | AT enfedulova morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren AT eazhukova morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren AT oatutina morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren AT takuznetsova morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren AT ovshumilova morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren AT ovfedorova morphologicalcriteriaforpredictionofseverityofcrohnsdiseaseclinicalcourseinchildren |