MORPHOLOGICAL CRITERIA FOR PREDICTION OF SEVERITY OF CROHN’S DISEASE CLINICAL COURSE IN CHILDREN
Aim: to establish prognostic morphological criteria of complicated clinical course of Crohn’s disease in children. Patients and methods: morphometric and histological characteristics of the mucous membrane of the large intestine were studied in 27 patients with colitis form of Crohn’s disease on the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2013-09-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/291 |
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| Summary: | Aim: to establish prognostic morphological criteria of complicated clinical course of Crohn’s disease in children. Patients and methods: morphometric and histological characteristics of the mucous membrane of the large intestine were studied in 27 patients with colitis form of Crohn’s disease on their first admission to a hospital. Results: the most informative predictive morphological criteria for unfavorable prognosis were the following: predominance of the non-active macrophages tending to aggregation in the lamina propria mucosae; destructive vasculitis; increase in the number of fibroblastic cells with the prevalence of the young forms. Non-active macrophages and immature fibroblasts under hypoxia conditions, associated with necrotizing vasculitits, are the factors which contribute to development of fibrosis in the mucous membrane of the large intestine. Conclusitons: unfavorable prognostic morphological criteria of Crohn’s disease were determined. These criteria allow using more aggressive treatment management («top-down» scheme) with early administration of steroid, cytostatic and anti-cytokine drugs in order to prevent the development of complications due to intestinal fibrosis. |
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| ISSN: | 1682-5527 1682-5535 |