Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis
Purpose Atopic dermatitis (AD), psoriasis and xerosis are characterized by alterations in the skin barrier leading to symptoms that severely impair patients’ quality of life (QoL). This multicenter, prospective study evaluated the benefits of a 4-week ceramide-containing regimen on the symptoms and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2486702 |
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| author | Carlota Abbad-Jaime de Aragon Emilio Berna-Rico Leonor Prieto Mercedes Abarquero-Cerezo Álvaro Gonzalez-Cantero |
| author_facet | Carlota Abbad-Jaime de Aragon Emilio Berna-Rico Leonor Prieto Mercedes Abarquero-Cerezo Álvaro Gonzalez-Cantero |
| author_sort | Carlota Abbad-Jaime de Aragon |
| collection | DOAJ |
| description | Purpose Atopic dermatitis (AD), psoriasis and xerosis are characterized by alterations in the skin barrier leading to symptoms that severely impair patients’ quality of life (QoL). This multicenter, prospective study evaluated the benefits of a 4-week ceramide-containing regimen on the symptoms and QoL of patients with AD, psoriasis, or xerosis.Materials and methods Clinical assessments (SCORAD, PASI, VAS), QoL and adherence to the treatment were evaluated at baseline and after 4 weeks.Results A total of 312 patients (109 AD, 97 psoriasis and 106 xerosis) participated in the study; 59.3% female, mean age 42.4 years, no family history of AD, psoriasis or xerosis in ∼70% of patients. Significant clinical improvements after 4 weeks were reported: 61.2% reduction in SCORAD in AD; 65.5% reduction in PASI in psoriasis; and reductions in VAS for dryness, erythema and other symptoms in xerosis patients. QoL improved in all groups (67.2% AD, 64.7% psoriasis, 77.3% xerosis), with a significant proportion of patients reducing their concomitant treatments. Most patients adhered to the regimen, and no adverse reactions were reported.Conclusions A ceramide-containing regimen reduced the symptoms commonly associated with AD, psoriasis, and xerosis and improves patients’ QoL. Limitations include the lack of control group and limiting conclusions about ceramides’ contribution on effectiveness. |
| format | Article |
| id | doaj-art-25764f4363c04a7d942e08dea3c497fa |
| institution | OA Journals |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-25764f4363c04a7d942e08dea3c497fa2025-08-20T02:08:42ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2486702Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosisCarlota Abbad-Jaime de Aragon0Emilio Berna-Rico1Leonor Prieto2Mercedes Abarquero-Cerezo3Álvaro Gonzalez-Cantero4Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainL’Oreal España S.A. Madrid, Madrid, SpainL’Oreal España S.A. Madrid, Madrid, SpainDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainPurpose Atopic dermatitis (AD), psoriasis and xerosis are characterized by alterations in the skin barrier leading to symptoms that severely impair patients’ quality of life (QoL). This multicenter, prospective study evaluated the benefits of a 4-week ceramide-containing regimen on the symptoms and QoL of patients with AD, psoriasis, or xerosis.Materials and methods Clinical assessments (SCORAD, PASI, VAS), QoL and adherence to the treatment were evaluated at baseline and after 4 weeks.Results A total of 312 patients (109 AD, 97 psoriasis and 106 xerosis) participated in the study; 59.3% female, mean age 42.4 years, no family history of AD, psoriasis or xerosis in ∼70% of patients. Significant clinical improvements after 4 weeks were reported: 61.2% reduction in SCORAD in AD; 65.5% reduction in PASI in psoriasis; and reductions in VAS for dryness, erythema and other symptoms in xerosis patients. QoL improved in all groups (67.2% AD, 64.7% psoriasis, 77.3% xerosis), with a significant proportion of patients reducing their concomitant treatments. Most patients adhered to the regimen, and no adverse reactions were reported.Conclusions A ceramide-containing regimen reduced the symptoms commonly associated with AD, psoriasis, and xerosis and improves patients’ QoL. Limitations include the lack of control group and limiting conclusions about ceramides’ contribution on effectiveness.https://www.tandfonline.com/doi/10.1080/09546634.2025.2486702Atopic dermatitisceramidespsoriasisquality of lifexerosis |
| spellingShingle | Carlota Abbad-Jaime de Aragon Emilio Berna-Rico Leonor Prieto Mercedes Abarquero-Cerezo Álvaro Gonzalez-Cantero Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis Journal of Dermatological Treatment Atopic dermatitis ceramides psoriasis quality of lifexerosis |
| title | Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis |
| title_full | Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis |
| title_fullStr | Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis |
| title_full_unstemmed | Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis |
| title_short | Improving the quality of life of patients with inflammatory skin diseases: a multicenter evaluation of a ceramide-containing regimen in patients with atopic dermatitis, psoriasis and xerosis |
| title_sort | improving the quality of life of patients with inflammatory skin diseases a multicenter evaluation of a ceramide containing regimen in patients with atopic dermatitis psoriasis and xerosis |
| topic | Atopic dermatitis ceramides psoriasis quality of lifexerosis |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2486702 |
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