FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was fo...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/462 |
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| author | T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin |
| author_facet | T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin |
| author_sort | T. E. Kissina |
| collection | DOAJ |
| description | Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production. |
| format | Article |
| id | doaj-art-2575e33c4f7b4fa488c1515a2e87d5fa |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-2575e33c4f7b4fa488c1515a2e87d5fa2025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-018450151010.15789/1563-0625-2006-4-501-510459FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGST. E. Kissina0I. S. Freidlin1B. E. Knoring2T. S. Basek3A. B. Elkin4ГУ Научно-исследовательский институт экспериментальной медицины РАМНГУ Научно-исследовательский институт экспериментальной медицины РАМНФГУ НИИ Фтизиопульмонологии РосздраваФГУ НИИ Фтизиопульмонологии РосздраваФГУ НИИ Фтизиопульмонологии РосздраваAbstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production.https://www.mimmun.ru/mimmun/article/view/462tuberculosisanergytuberculincytokinesmononuclear cells |
| spellingShingle | T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS Медицинская иммунология tuberculosis anergy tuberculin cytokines mononuclear cells |
| title | FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS |
| title_full | FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS |
| title_fullStr | FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS |
| title_full_unstemmed | FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS |
| title_short | FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS |
| title_sort | features of specific immune response in the patients with fibrous cavernous tuberculosis of lungs |
| topic | tuberculosis anergy tuberculin cytokines mononuclear cells |
| url | https://www.mimmun.ru/mimmun/article/view/462 |
| work_keys_str_mv | AT tekissina featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT isfreidlin featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT beknoring featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT tsbasek featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT abelkin featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs |