Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes
This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Mean regional retinal thickness of 11 retinal layers was obtained by automatic three-dimension...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/259123 |
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| author | Raheleh Kafieh Hossein Rabbani Fedra Hajizadeh Michael D. Abramoff Milan Sonka |
| author_facet | Raheleh Kafieh Hossein Rabbani Fedra Hajizadeh Michael D. Abramoff Milan Sonka |
| author_sort | Raheleh Kafieh |
| collection | DOAJ |
| description | This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Mean regional retinal thickness of 11 retinal layers was obtained by automatic three-dimensional diffusion map based method in 112 normal eyes of 76 Iranian subjects. We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture. The thickness maps are compared among 9 macular sectors within 3 concentric circles as defined by ETDRS. The thickness map of central foveal area in layers 1, 3, and 4 displayed the minimum thickness. Maximum thickness was observed in nasal to the fovea of layer 1 and in a circular pattern in the parafoveal retinal area of layers 2, 3, and 4 and in central foveal area of layer 6. Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women. Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age. |
| format | Article |
| id | doaj-art-2574ba2ff6fc42af813225f3024cb31a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2574ba2ff6fc42af813225f3024cb31a2025-02-03T01:21:39ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/259123259123Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal EyesRaheleh Kafieh0Hossein Rabbani1Fedra Hajizadeh2Michael D. Abramoff3Milan Sonka4Biomedical Engineering Department, Medical Image & Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranBiomedical Engineering Department, Medical Image & Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan 81745, IranNoor Ophthalmology Research Center, Tehran 1968653111, IranDepartment of Ophthalmology & Visual Science, The University of Iowa, Iowa City, IA 52242, USAThe Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USAThis study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Mean regional retinal thickness of 11 retinal layers was obtained by automatic three-dimensional diffusion map based method in 112 normal eyes of 76 Iranian subjects. We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture. The thickness maps are compared among 9 macular sectors within 3 concentric circles as defined by ETDRS. The thickness map of central foveal area in layers 1, 3, and 4 displayed the minimum thickness. Maximum thickness was observed in nasal to the fovea of layer 1 and in a circular pattern in the parafoveal retinal area of layers 2, 3, and 4 and in central foveal area of layer 6. Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women. Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age.http://dx.doi.org/10.1155/2015/259123 |
| spellingShingle | Raheleh Kafieh Hossein Rabbani Fedra Hajizadeh Michael D. Abramoff Milan Sonka Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes Journal of Ophthalmology |
| title | Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes |
| title_full | Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes |
| title_fullStr | Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes |
| title_full_unstemmed | Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes |
| title_short | Thickness Mapping of Eleven Retinal Layers Segmented Using the Diffusion Maps Method in Normal Eyes |
| title_sort | thickness mapping of eleven retinal layers segmented using the diffusion maps method in normal eyes |
| url | http://dx.doi.org/10.1155/2015/259123 |
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