Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial
Objectives Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous...
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Korea Disease Control and Prevention Agency
2024-12-01
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| Series: | Osong Public Health and Research Perspectives |
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| Online Access: | http://ophrp.org/upload/pdf/j-phrp-2024-0187.pdf |
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| author | Azam Ildarabadi Marzieh Vahid-Dastjerdi Mina Ghorbanpour Ahmad Mousavi Mehrnoush Meshkani Mirsaeed Yekaninejad Ahmad Saedisomeolia |
| author_facet | Azam Ildarabadi Marzieh Vahid-Dastjerdi Mina Ghorbanpour Ahmad Mousavi Mehrnoush Meshkani Mirsaeed Yekaninejad Ahmad Saedisomeolia |
| author_sort | Azam Ildarabadi |
| collection | DOAJ |
| description | Objectives Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS. Methods This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n=22) received 400 mg of green coffee supplements, while the control group (n=22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p=0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p=0.013) and triglyceride levels by 6.1 units (p=0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status. |
| format | Article |
| id | doaj-art-2572e2f72f5243ff8e1cbf81be6d9c13 |
| institution | DOAJ |
| issn | 2233-6052 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korea Disease Control and Prevention Agency |
| record_format | Article |
| series | Osong Public Health and Research Perspectives |
| spelling | doaj-art-2572e2f72f5243ff8e1cbf81be6d9c132025-08-20T03:02:18ZengKorea Disease Control and Prevention AgencyOsong Public Health and Research Perspectives2233-60522024-12-0115652153210.24171/j.phrp.2024.0187804Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trialAzam Ildarabadi0Marzieh Vahid-Dastjerdi1Mina Ghorbanpour2Ahmad Mousavi3Mehrnoush Meshkani4Mirsaeed Yekaninejad5Ahmad Saedisomeolia6 Department of Nutrition Science, Science and Research Branch, Faculty of Medical Science and Technology, Islamic Azad University, Tehran, Iran Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Science, Tehran, Iran University Research and Development Center, Tehran University of Medical Sciences, Tehran, Iran Department of Nutrition Science, Science and Research Branch, Faculty of Medical Science and Technology, Islamic Azad University, Tehran, Iran Department of Nutrition Science, Science and Research Branch, Faculty of Medical Science and Technology, Islamic Azad University, Tehran, Iran Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran Higher Education College of Health Sciences, Education Centre of Australia, Parramatta, NSW, AustraliaObjectives Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS. Methods This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n=22) received 400 mg of green coffee supplements, while the control group (n=22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p=0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p=0.013) and triglyceride levels by 6.1 units (p=0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.http://ophrp.org/upload/pdf/j-phrp-2024-0187.pdfchlorogenic acidglycemic indexgreen coffeelipid profilepolycystic ovary syndrome |
| spellingShingle | Azam Ildarabadi Marzieh Vahid-Dastjerdi Mina Ghorbanpour Ahmad Mousavi Mehrnoush Meshkani Mirsaeed Yekaninejad Ahmad Saedisomeolia Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial Osong Public Health and Research Perspectives chlorogenic acid glycemic index green coffee lipid profile polycystic ovary syndrome |
| title | Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial |
| title_full | Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial |
| title_fullStr | Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial |
| title_full_unstemmed | Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial |
| title_short | Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial |
| title_sort | effects of green coffee supplementation on paraoxonase 1 activity and malondialdehyde levels in iranian women with polycystic ovary syndrome a randomized clinical trial |
| topic | chlorogenic acid glycemic index green coffee lipid profile polycystic ovary syndrome |
| url | http://ophrp.org/upload/pdf/j-phrp-2024-0187.pdf |
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