The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort
Introduction. The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort. Patients and Methods. The study cohort comprised 142 German children (age 5–9 years, 9...
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/205079 |
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| author | Marcin Krawczyk Roman Liebe Ina B. Maier Anna Janina Engstler Frank Lammert Ina Bergheim |
| author_facet | Marcin Krawczyk Roman Liebe Ina B. Maier Anna Janina Engstler Frank Lammert Ina Bergheim |
| author_sort | Marcin Krawczyk |
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| description | Introduction. The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort. Patients and Methods. The study cohort comprised 142 German children (age 5–9 years, 98 overweight, 19 children with NAFLD). Results. Overweight children presented with increased serum ALT (P=0.001) and GGT (P<0.001) activities. ALT activities differed significantly (P=0.02) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children (P=0.02) and in children younger than 7 years (P=0.02). Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile (P=0.01). The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype (P<0.001 and P=0.06, resp.). The variant was associated with increased serum glucose levels (P=0.01) and HOMA index (P=0.02) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD. Discussion. The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities already at a young age. |
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| id | doaj-art-256a97cb30c340e8af240a83222bcb60 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
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| spelling | doaj-art-256a97cb30c340e8af240a83222bcb602025-08-20T02:04:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/205079205079The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric CohortMarcin Krawczyk0Roman Liebe1Ina B. Maier2Anna Janina Engstler3Frank Lammert4Ina Bergheim5Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, GermanyDepartment of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, GermanyDepartment of Nutritional Medicine, Universität Hohenheim, 70599 Stuttgart, GermanyDepartment of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-Universität, 07743 Jena, GermanyDepartment of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, GermanyDepartment of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-Universität, 07743 Jena, GermanyIntroduction. The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort. Patients and Methods. The study cohort comprised 142 German children (age 5–9 years, 98 overweight, 19 children with NAFLD). Results. Overweight children presented with increased serum ALT (P=0.001) and GGT (P<0.001) activities. ALT activities differed significantly (P=0.02) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children (P=0.02) and in children younger than 7 years (P=0.02). Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile (P=0.01). The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype (P<0.001 and P=0.06, resp.). The variant was associated with increased serum glucose levels (P=0.01) and HOMA index (P=0.02) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD. Discussion. The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities already at a young age.http://dx.doi.org/10.1155/2015/205079 |
| spellingShingle | Marcin Krawczyk Roman Liebe Ina B. Maier Anna Janina Engstler Frank Lammert Ina Bergheim The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort Gastroenterology Research and Practice |
| title | The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort |
| title_full | The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort |
| title_fullStr | The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort |
| title_full_unstemmed | The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort |
| title_short | The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort |
| title_sort | frequent adiponutrin pnpla3 variant p ile148met is associated with early liver injury analysis of a german pediatric cohort |
| url | http://dx.doi.org/10.1155/2015/205079 |
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