Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review
Abstract In the progression of gastric cancer (GC), various cell types in the tumor microenvironment (TME) exhibit upregulated expression of programmed death ligand 1 (PD-L1), leading to impaired T-cell function and evasion of immune surveillance. Infection with H. pylori and EBV leads to increased...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | Biological Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40659-025-00597-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390349866237952 |
|---|---|
| author | Peifeng Chen Zhangming Chen Wannian Sui Wenxiu Han |
| author_facet | Peifeng Chen Zhangming Chen Wannian Sui Wenxiu Han |
| author_sort | Peifeng Chen |
| collection | DOAJ |
| description | Abstract In the progression of gastric cancer (GC), various cell types in the tumor microenvironment (TME) exhibit upregulated expression of programmed death ligand 1 (PD-L1), leading to impaired T-cell function and evasion of immune surveillance. Infection with H. pylori and EBV leads to increased PD-L1 expression in various cell types within TME, resulting in immune suppression and facilitating immune escape of GC cells. In the TME, mesenchymal stem cells (MSCs), M1-like tumor-associated macrophages (MI-like TAM), and myeloid-derived suppressor cells (MDSCs) contribute to the upregulation of PD-L1 expression in GC cells. Conversely, mast cells, M2-like tumor-associated macrophages (M2-like TAM), and tumor-associated neutrophils (TANs) exhibit elevated levels of PD-L1 expression in response to the influence of GC cells. Together, these factors collectively contribute to the upregulation of PD-L1 expression in GC. This review aims to provide a comprehensive summary of the cellular expression patterns of PD-L1 in GC and the underlying molecular mechanisms. Understanding the complex regulatory pathways governing PD-L1 expression may offer novel insights for the development of effective immunotherapeutic interventions. |
| format | Article |
| id | doaj-art-256225d0d26f41e69d8b831ae2dfad92 |
| institution | Kabale University |
| issn | 0717-6287 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj-art-256225d0d26f41e69d8b831ae2dfad922025-08-20T03:41:41ZengBMCBiological Research0717-62872025-03-0158111410.1186/s40659-025-00597-3Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a reviewPeifeng Chen0Zhangming Chen1Wannian Sui2Wenxiu Han3Department of General Surgery, First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityAbstract In the progression of gastric cancer (GC), various cell types in the tumor microenvironment (TME) exhibit upregulated expression of programmed death ligand 1 (PD-L1), leading to impaired T-cell function and evasion of immune surveillance. Infection with H. pylori and EBV leads to increased PD-L1 expression in various cell types within TME, resulting in immune suppression and facilitating immune escape of GC cells. In the TME, mesenchymal stem cells (MSCs), M1-like tumor-associated macrophages (MI-like TAM), and myeloid-derived suppressor cells (MDSCs) contribute to the upregulation of PD-L1 expression in GC cells. Conversely, mast cells, M2-like tumor-associated macrophages (M2-like TAM), and tumor-associated neutrophils (TANs) exhibit elevated levels of PD-L1 expression in response to the influence of GC cells. Together, these factors collectively contribute to the upregulation of PD-L1 expression in GC. This review aims to provide a comprehensive summary of the cellular expression patterns of PD-L1 in GC and the underlying molecular mechanisms. Understanding the complex regulatory pathways governing PD-L1 expression may offer novel insights for the development of effective immunotherapeutic interventions.https://doi.org/10.1186/s40659-025-00597-3Gastric cancerProgrammed death ligand 1Tumor immunityTumor microenvironment |
| spellingShingle | Peifeng Chen Zhangming Chen Wannian Sui Wenxiu Han Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review Biological Research Gastric cancer Programmed death ligand 1 Tumor immunity Tumor microenvironment |
| title | Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review |
| title_full | Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review |
| title_fullStr | Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review |
| title_full_unstemmed | Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review |
| title_short | Recent advances in the mechanisms of PD-L1 expression in gastric cancer: a review |
| title_sort | recent advances in the mechanisms of pd l1 expression in gastric cancer a review |
| topic | Gastric cancer Programmed death ligand 1 Tumor immunity Tumor microenvironment |
| url | https://doi.org/10.1186/s40659-025-00597-3 |
| work_keys_str_mv | AT peifengchen recentadvancesinthemechanismsofpdl1expressioningastriccancerareview AT zhangmingchen recentadvancesinthemechanismsofpdl1expressioningastriccancerareview AT wanniansui recentadvancesinthemechanismsofpdl1expressioningastriccancerareview AT wenxiuhan recentadvancesinthemechanismsofpdl1expressioningastriccancerareview |