CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES
Objective: specify peculiarities of calcium and phosphates excretion in neonates of various gestational ages and types of feeding in neonatal period. Patients and methods. Calcium-creatinine (Ca/Cr) and phosphate-creatinine (P/Cr) ratio concentrations were determined in 96 healthy neonates of 38-40...
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Union of pediatricians of Russia
2014-03-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/123 |
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| author | O. I. Fomina T. A. Kuznetsova A. V. Shulga |
| author_facet | O. I. Fomina T. A. Kuznetsova A. V. Shulga |
| author_sort | O. I. Fomina |
| collection | DOAJ |
| description | Objective: specify peculiarities of calcium and phosphates excretion in neonates of various gestational ages and types of feeding in neonatal period. Patients and methods. Calcium-creatinine (Ca/Cr) and phosphate-creatinine (P/Cr) ratio concentrations were determined in 96 healthy neonates of 38-40 weeks of gestational age and 146 premature infants of 28-37 weeks of gestational age of various types of feeding. Results. The Ca/Cr ratio concentration in healthy term infants in the early neonatal period amounted to 0.9-2.2 (median – 1.8), the P/Cr ratio concentration – 0.8-2.1 (median – 1.6). The Ca/Cr ratio concentration in premature infants (28-37 weeks of gestational age) amounted to 0.9-2.4 (median – 1.9), which is comparable to this parameter’s value in term infants. The P/Cr ratio concentration amounted to 0.7-3.1 (median – 2.4), which exceeds this parameter’s value in term infants. The lesser the gestational age and birth weight, the higher the Ca/Cr and P/Cr ratio concentrations. The authors revealed hypercalciuria and hyperphosphaturia in premature infants with a very low body weight fed with specialized formulas. Conclusions. Use of specialized formulas in small premature infants (gestational age < 33 weeks) with VLBW results in excessive calcium and phosphates excretion. It is reasonable to monitor their concentrations using a non-invasive and informative method of determining Ca/Cr and P/Cr ratios. Feeding of premature infants with BW > 1,500 g with breast milk only (in case of the mother’s adequate lactation) allows avoiding hypercalciuria and hyperphosphaturia and preventing risk of a renal pathology. |
| format | Article |
| id | doaj-art-2560ed0a03ab48b79146e90fc9b976a7 |
| institution | Kabale University |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2014-03-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-2560ed0a03ab48b79146e90fc9b976a72025-08-20T03:36:53ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892014-03-01112727710.15690/pf.v11i2.961123CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGESO. I. Fomina0T. A. Kuznetsova1A. V. Shulga2Orel State University, Medical School Regional children’s clinical hospital, OrelOrel State University, Medical School, Russian FederationOrel State University, Medical School, Russian Federation Regional Children’s Clinicalhospital, Orel, Russian FederationObjective: specify peculiarities of calcium and phosphates excretion in neonates of various gestational ages and types of feeding in neonatal period. Patients and methods. Calcium-creatinine (Ca/Cr) and phosphate-creatinine (P/Cr) ratio concentrations were determined in 96 healthy neonates of 38-40 weeks of gestational age and 146 premature infants of 28-37 weeks of gestational age of various types of feeding. Results. The Ca/Cr ratio concentration in healthy term infants in the early neonatal period amounted to 0.9-2.2 (median – 1.8), the P/Cr ratio concentration – 0.8-2.1 (median – 1.6). The Ca/Cr ratio concentration in premature infants (28-37 weeks of gestational age) amounted to 0.9-2.4 (median – 1.9), which is comparable to this parameter’s value in term infants. The P/Cr ratio concentration amounted to 0.7-3.1 (median – 2.4), which exceeds this parameter’s value in term infants. The lesser the gestational age and birth weight, the higher the Ca/Cr and P/Cr ratio concentrations. The authors revealed hypercalciuria and hyperphosphaturia in premature infants with a very low body weight fed with specialized formulas. Conclusions. Use of specialized formulas in small premature infants (gestational age < 33 weeks) with VLBW results in excessive calcium and phosphates excretion. It is reasonable to monitor their concentrations using a non-invasive and informative method of determining Ca/Cr and P/Cr ratios. Feeding of premature infants with BW > 1,500 g with breast milk only (in case of the mother’s adequate lactation) allows avoiding hypercalciuria and hyperphosphaturia and preventing risk of a renal pathology.https://www.pedpharma.ru/jour/article/view/123neonatespremature infantscalcium excretionphosphorus excretioncalcium-creatinine (ca/cr) ratiophosphate-creatinine (p/cr) ratio |
| spellingShingle | O. I. Fomina T. A. Kuznetsova A. V. Shulga CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES Педиатрическая фармакология neonates premature infants calcium excretion phosphorus excretion calcium-creatinine (ca/cr) ratio phosphate-creatinine (p/cr) ratio |
| title | CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES |
| title_full | CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES |
| title_fullStr | CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES |
| title_full_unstemmed | CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES |
| title_short | CALCIUM, CREATININE AND URINARY PHOSPHATE/CREATININE RATIO CONCENTRATIONS IN NEONATES OF VARIOUS GESTATIONAL AGES |
| title_sort | calcium creatinine and urinary phosphate creatinine ratio concentrations in neonates of various gestational ages |
| topic | neonates premature infants calcium excretion phosphorus excretion calcium-creatinine (ca/cr) ratio phosphate-creatinine (p/cr) ratio |
| url | https://www.pedpharma.ru/jour/article/view/123 |
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