Comparative effectiveness of plant-derived compounds in keloid management: a review
Keloids are a challenging dermatological condition characterized by excessive scar formation beyond the original wound site, high recurrence rates, and limited treatment efficacy. Current therapies, such as corticosteroids, surgery, and radiotherapy, often yield suboptimal outcomes and adverse effec...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1576851/full |
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| author | Arya Tjipta Prananda Sony Eka Nugraha Putri Cahaya Situmorang Rony Abdi Syahputra |
| author_facet | Arya Tjipta Prananda Sony Eka Nugraha Putri Cahaya Situmorang Rony Abdi Syahputra |
| author_sort | Arya Tjipta Prananda |
| collection | DOAJ |
| description | Keloids are a challenging dermatological condition characterized by excessive scar formation beyond the original wound site, high recurrence rates, and limited treatment efficacy. Current therapies, such as corticosteroids, surgery, and radiotherapy, often yield suboptimal outcomes and adverse effects. This review evaluates the potential of plant-derived metabolites as safer and more effective alternatives for keloid management. Preclinical and clinical studies demonstrate that compounds like curcumin, epigallocatechin gallate (EGCG), and asiaticoside exhibit anti-fibrotic, anti-inflammatory, and antioxidant properties by modulating key pathways (e.g., TGF-β/Smad, NF-κB, and oxidative stress). Espite promising preclinical and early clinical findings, critical challenges hinder the clinical translation of these metabolites. These include poor and variable bioavailability, inconsistencies in extract standardization, and a paucity of large-scale, rigorously designed trials. Moreover, some metabolites may yield conflicting results or exhibit off-target effects in in vitro systems, necessitating caution in interpreting their true therapeutic potential. Future research should focus on optimizing drug delivery systems, conducting large-scale trials, and integrating personalized medicine approaches. Plant-derived metabolites represent a multi-targeted therapeutic strategy with the potential to address unmet needs in keloid treatment. |
| format | Article |
| id | doaj-art-255f13c24c734e6491fdcee4a820482f |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-255f13c24c734e6491fdcee4a820482f2025-08-20T02:40:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15768511576851Comparative effectiveness of plant-derived compounds in keloid management: a reviewArya Tjipta Prananda0Sony Eka Nugraha1Putri Cahaya Situmorang2Rony Abdi Syahputra3Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, IndonesiaStudy Program of Biology, Faculty of Mathematic and Natural Science, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, IndonesiaKeloids are a challenging dermatological condition characterized by excessive scar formation beyond the original wound site, high recurrence rates, and limited treatment efficacy. Current therapies, such as corticosteroids, surgery, and radiotherapy, often yield suboptimal outcomes and adverse effects. This review evaluates the potential of plant-derived metabolites as safer and more effective alternatives for keloid management. Preclinical and clinical studies demonstrate that compounds like curcumin, epigallocatechin gallate (EGCG), and asiaticoside exhibit anti-fibrotic, anti-inflammatory, and antioxidant properties by modulating key pathways (e.g., TGF-β/Smad, NF-κB, and oxidative stress). Espite promising preclinical and early clinical findings, critical challenges hinder the clinical translation of these metabolites. These include poor and variable bioavailability, inconsistencies in extract standardization, and a paucity of large-scale, rigorously designed trials. Moreover, some metabolites may yield conflicting results or exhibit off-target effects in in vitro systems, necessitating caution in interpreting their true therapeutic potential. Future research should focus on optimizing drug delivery systems, conducting large-scale trials, and integrating personalized medicine approaches. Plant-derived metabolites represent a multi-targeted therapeutic strategy with the potential to address unmet needs in keloid treatment.https://www.frontiersin.org/articles/10.3389/fphar.2025.1576851/fullkeloid managementplant-derived metabolitesanti-fibrotic therapybioavailability challengespersonalized medicine |
| spellingShingle | Arya Tjipta Prananda Sony Eka Nugraha Putri Cahaya Situmorang Rony Abdi Syahputra Comparative effectiveness of plant-derived compounds in keloid management: a review Frontiers in Pharmacology keloid management plant-derived metabolites anti-fibrotic therapy bioavailability challenges personalized medicine |
| title | Comparative effectiveness of plant-derived compounds in keloid management: a review |
| title_full | Comparative effectiveness of plant-derived compounds in keloid management: a review |
| title_fullStr | Comparative effectiveness of plant-derived compounds in keloid management: a review |
| title_full_unstemmed | Comparative effectiveness of plant-derived compounds in keloid management: a review |
| title_short | Comparative effectiveness of plant-derived compounds in keloid management: a review |
| title_sort | comparative effectiveness of plant derived compounds in keloid management a review |
| topic | keloid management plant-derived metabolites anti-fibrotic therapy bioavailability challenges personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1576851/full |
| work_keys_str_mv | AT aryatjiptaprananda comparativeeffectivenessofplantderivedcompoundsinkeloidmanagementareview AT sonyekanugraha comparativeeffectivenessofplantderivedcompoundsinkeloidmanagementareview AT putricahayasitumorang comparativeeffectivenessofplantderivedcompoundsinkeloidmanagementareview AT ronyabdisyahputra comparativeeffectivenessofplantderivedcompoundsinkeloidmanagementareview |