Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies
The hydrazones and their metal complexes find application as anticancer, antibacterial, chemotherapeutic, antioxidants, and antiproliferative agents, among several other uses. In our quest for possible bioactive hydrazone and complexes, we have synthesized novel Zn(II) and Fe(II) metal complexes of...
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Nigerian Society of Physical Sciences
2025-02-01
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| Series: | Journal of Nigerian Society of Physical Sciences |
| Online Access: | https://journal.nsps.org.ng/index.php/jnsps/article/view/2326 |
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| author | K. O. Eberendu J. I. Iheanyichukwu O. M. Mac-kalunta C. I. Nwankwo I. E. Otuokere J. C. Nnaji |
| author_facet | K. O. Eberendu J. I. Iheanyichukwu O. M. Mac-kalunta C. I. Nwankwo I. E. Otuokere J. C. Nnaji |
| author_sort | K. O. Eberendu |
| collection | DOAJ |
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The hydrazones and their metal complexes find application as anticancer, antibacterial, chemotherapeutic, antioxidants, and antiproliferative agents, among several other uses. In our quest for possible bioactive hydrazone and complexes, we have synthesized novel Zn(II) and Fe(II) metal complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitro-phenyl) prop-2-enylidene] amino. The octahedral geometry of the complexes was further supported by the spectral methods, with coordination proceeding through two nitro groups, two chloride atoms, an NH group, and an azomethine nitrogen atom. From the fact noted, we can now confirm that Zn(II) and Fe(II) can coordinate DNEAA to form complexes of high stability. The molecular docking study showed binding energies to be above -9.6 Kcal/mol. These results recommend biological, preclinical, and clinical trials take place, with the target being SARS-CoV-2 protease
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| format | Article |
| id | doaj-art-255908db3ffc4c2db2f66b6f276ee9ed |
| institution | DOAJ |
| issn | 2714-2817 2714-4704 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nigerian Society of Physical Sciences |
| record_format | Article |
| series | Journal of Nigerian Society of Physical Sciences |
| spelling | doaj-art-255908db3ffc4c2db2f66b6f276ee9ed2025-08-20T03:00:55ZengNigerian Society of Physical SciencesJournal of Nigerian Society of Physical Sciences2714-28172714-47042025-02-017110.46481/jnsps.2025.2326Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studiesK. O. Eberendu 0J. I. Iheanyichukwu1O. M. Mac-kalunta2C. I. Nwankwo3I. E. Otuokere4J. C. Nnaji5Department of Chemistry, Spiritan University, Nneochi, Abia, NigeriaDepartment of Chemistry, Michael Okpara University of Agriculture, NigeriaDepartment of Chemistry, Michael Okpara University of Agriculture, NigeriaDepartment of Biochemistry, Michael Okpara University of Agriculture, NigeriaDepartment of Chemistry, Michael Okpara University of Agriculture, NigeriaDepartment of Chemistry, Michael Okpara University of Agriculture, Nigeria The hydrazones and their metal complexes find application as anticancer, antibacterial, chemotherapeutic, antioxidants, and antiproliferative agents, among several other uses. In our quest for possible bioactive hydrazone and complexes, we have synthesized novel Zn(II) and Fe(II) metal complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitro-phenyl) prop-2-enylidene] amino. The octahedral geometry of the complexes was further supported by the spectral methods, with coordination proceeding through two nitro groups, two chloride atoms, an NH group, and an azomethine nitrogen atom. From the fact noted, we can now confirm that Zn(II) and Fe(II) can coordinate DNEAA to form complexes of high stability. The molecular docking study showed binding energies to be above -9.6 Kcal/mol. These results recommend biological, preclinical, and clinical trials take place, with the target being SARS-CoV-2 protease https://journal.nsps.org.ng/index.php/jnsps/article/view/2326 |
| spellingShingle | K. O. Eberendu J. I. Iheanyichukwu O. M. Mac-kalunta C. I. Nwankwo I. E. Otuokere J. C. Nnaji Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies Journal of Nigerian Society of Physical Sciences |
| title | Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies |
| title_full | Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies |
| title_fullStr | Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies |
| title_full_unstemmed | Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies |
| title_short | Zn(II) and Fe(II) complexes of 2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies |
| title_sort | zn ii and fe ii complexes of 2 4 dinitro n z e 3 2 nitrophenyl prop 2 enylidene amino aniline synthesis characterization and in silico sars cov 2 inhibition studies |
| url | https://journal.nsps.org.ng/index.php/jnsps/article/view/2326 |
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