Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the process

Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the process

Regorafenib is administered orally for the treatment of metastatic colorectal cancer. However, its limited water solubility hinders its clinical efficacy. This study explores the impregnation of regorafenib monohydrate (REG MH) into pullulan (PULL) using supercritical carbon dioxide (scCO2), aiming...

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Bibliographic Details
Main Authors: Ali Sheikhi, Sepideh Hamedi, Gholamhossein Sodeifian, Fariba Razmimanesh
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of CO2 Utilization
Subjects:
supercritical CO2 impregnation
optimization
pullulan exopolysaccharide
promoted REG dissolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2212982025000241
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