Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings
The aim of review. To assess clinical efficacy of antisecretory drugs at gastroduodenal ulcer bleedings.Original positions. Parenteral forms of Н2-blockers as conservative hemostasis components showed efficacy which statistically does not differ from that of placebo. Metaanalysis of 18 studies revea...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1525 |
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| _version_ | 1823860260053450752 |
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| author | M. A. Evseyev I. M. Klishin |
| author_facet | M. A. Evseyev I. M. Klishin |
| author_sort | M. A. Evseyev |
| collection | DOAJ |
| description | The aim of review. To assess clinical efficacy of antisecretory drugs at gastroduodenal ulcer bleedings.Original positions. Parenteral forms of Н2-blockers as conservative hemostasis components showed efficacy which statistically does not differ from that of placebo. Metaanalysis of 18 studies revealed, that continuous intravenous infusion of omeprazole significantly reduces frequency of recurrent hemorrhage. Parenteral injection of esomeprazole after endoscopic hemostasis provides highly effective decrease in frequency of recurrent ulcer bleeding in the first 72 hs of hospital stay, as well as for the next 7 and 30 days.Conclusion. Prolonged intravenous injection of esomeprazole with subsequent intake of the drug per os is proved for application in clinical practice for patients with bleeding stomach and duodenum ulcers after endoscopical verification of hemostasis. |
| format | Article |
| id | doaj-art-2554dc83ba33414abe4b0a36db25abb1 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-2554dc83ba33414abe4b0a36db25abb12025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-06-0120355621042Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedingsM. A. Evseyev0I. M. Klishin1Московская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваThe aim of review. To assess clinical efficacy of antisecretory drugs at gastroduodenal ulcer bleedings.Original positions. Parenteral forms of Н2-blockers as conservative hemostasis components showed efficacy which statistically does not differ from that of placebo. Metaanalysis of 18 studies revealed, that continuous intravenous infusion of omeprazole significantly reduces frequency of recurrent hemorrhage. Parenteral injection of esomeprazole after endoscopic hemostasis provides highly effective decrease in frequency of recurrent ulcer bleeding in the first 72 hs of hospital stay, as well as for the next 7 and 30 days.Conclusion. Prolonged intravenous injection of esomeprazole with subsequent intake of the drug per os is proved for application in clinical practice for patients with bleeding stomach and duodenum ulcers after endoscopical verification of hemostasis.https://www.gastro-j.ru/jour/article/view/1525gastroduodenal ulcerative bleedingsantisecretory drugsн2-blockersproton pump inhibitorsfamotidineomeprazoleesomeprazole |
| spellingShingle | M. A. Evseyev I. M. Klishin Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastroduodenal ulcerative bleedings antisecretory drugs н2-blockers proton pump inhibitors famotidine omeprazole esomeprazole |
| title | Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| title_full | Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| title_fullStr | Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| title_full_unstemmed | Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| title_short | Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| title_sort | antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings |
| topic | gastroduodenal ulcerative bleedings antisecretory drugs н2-blockers proton pump inhibitors famotidine omeprazole esomeprazole |
| url | https://www.gastro-j.ru/jour/article/view/1525 |
| work_keys_str_mv | AT maevseyev antisecretorytreatmentefficacybyprotonpumpinhibitorsatgastroduodenalulcerbleedings AT imklishin antisecretorytreatmentefficacybyprotonpumpinhibitorsatgastroduodenalulcerbleedings |