SARS-CoV-2 ORF7a activates the endothelium to release von Willebrand factor that promotes thrombosis

SARS-CoV-2 ORF7a activates the endothelium to release von Willebrand factor that promotes thrombosis

Background: Patients with severe and critical COVID-19 frequently exhibit thromboembolic complications, a significant cause of mortality and morbidity. Increased plasma levels of von Willebrand factor (VWF) following SARS-CoV-2 infection have been extensively reported, which links to thrombosis and...

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Bibliographic Details
Main Authors: Quan Zhang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Szumam Liu, Shiwani Limbu, Malay K. Basu, Joyce van de Leemput, Felice D’Agnillo, Zhe Han, X. Long Zheng
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
ADAMTS-13
coagulation
endothelium
Hml
Orf7a
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925002717
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