IL- 33 and sST- 2 association with carotid intima-media thickness in patients with Ankylosing Spondylitis
Abstract Background Cardiovascular disease is the main cause of death in patients with ankylosing spondylitis (AS). Previous studies showed high serum levels of IL- 33 in AS patients and suggested that it may play a role in disease development. However, the possible role of IL- 33/sST- 2 in atherosc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-06-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-025-00324-6 |
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| Summary: | Abstract Background Cardiovascular disease is the main cause of death in patients with ankylosing spondylitis (AS). Previous studies showed high serum levels of IL- 33 in AS patients and suggested that it may play a role in disease development. However, the possible role of IL- 33/sST- 2 in atherosclerosis in AS has not been investigated. Objectives To assess serum levels of IL- 33 and sST- 2 and to assess their association with carotid intima-media thickness (CIMT) and disease activity in a group of Egyptian patients with AS. Results Serum levels of IL- 33 and sST- 2 were statistically higher in AS patients compared to controls (median, 451.75 vs 37.42, p = 0.000) and (median, 5.71 vs 0.74, p = 0.000) respectively. IL- 33 and sST- 2 levels positively correlated with Bath Ankylosing Spondylitis Disease Activity Index (r = 0.445, p = 0.004) and (r = 0.421, p = 0.007) respectively, and Ankylosing Spondylitis Disease Activity Score with CRP (r = 0.684, p = 0.000) and (r = 0.452, p = 0.003) respectively. There was a positive correlation between serum IL- 33/sST- 2 and CIMT. Conclusion The high serum levels of IL- 33 and sST- 2 in AS patients and their positive correlation with CIMT and AS disease activity suggest that IL- 33/ST2 axis-induced inflammation may be a major factor in the development of cardiovascular disease in AS patients. |
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| ISSN: | 2090-3235 |