The Role of Chemerin in Neutrophil Activation and Diseases of the Lung
Chemerin is an adipokine with complex biochemistry that undergoes proteolytic modification by components of the inflammatory, coagulation, and fibrinolytic systems, generating both active and inactive products. Chemerin has been found to have both pro- and anti-inflammatory properties, can regulate...
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MDPI AG
2025-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/6/1354 |
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| author | Patrick Arndt |
| author_facet | Patrick Arndt |
| author_sort | Patrick Arndt |
| collection | DOAJ |
| description | Chemerin is an adipokine with complex biochemistry that undergoes proteolytic modification by components of the inflammatory, coagulation, and fibrinolytic systems, generating both active and inactive products. Chemerin has been found to have both pro- and anti-inflammatory properties, can regulate angiogenesis, and is involved in cancer pathogenesis. Although chemerin is a chemoattractant for macrophages, plasmacytoid dendritic cells, and natural killer cells, it does not induce neutrophil chemotaxis. In contrast, neutrophils appear to act on chemerin structure and localization to regulate the inflammatory response. A role for chemerin in several lung diseases, including airway disease, interstitial lung disease, and cancer, has begun to be explored, but its full role is yet to be fully understood. This review will discuss the role of chemerin in neutrophil activation and will examine what is currently known of the effect of chemerin in diseases of the lung. |
| format | Article |
| id | doaj-art-254e7039e72f43cd8db70b260ce6c56d |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-254e7039e72f43cd8db70b260ce6c56d2025-08-20T03:26:17ZengMDPI AGBiomedicines2227-90592025-05-01136135410.3390/biomedicines13061354The Role of Chemerin in Neutrophil Activation and Diseases of the LungPatrick Arndt0Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, MN 55455, USAChemerin is an adipokine with complex biochemistry that undergoes proteolytic modification by components of the inflammatory, coagulation, and fibrinolytic systems, generating both active and inactive products. Chemerin has been found to have both pro- and anti-inflammatory properties, can regulate angiogenesis, and is involved in cancer pathogenesis. Although chemerin is a chemoattractant for macrophages, plasmacytoid dendritic cells, and natural killer cells, it does not induce neutrophil chemotaxis. In contrast, neutrophils appear to act on chemerin structure and localization to regulate the inflammatory response. A role for chemerin in several lung diseases, including airway disease, interstitial lung disease, and cancer, has begun to be explored, but its full role is yet to be fully understood. This review will discuss the role of chemerin in neutrophil activation and will examine what is currently known of the effect of chemerin in diseases of the lung.https://www.mdpi.com/2227-9059/13/6/1354chemerinneutrophillungcancerCOPD |
| spellingShingle | Patrick Arndt The Role of Chemerin in Neutrophil Activation and Diseases of the Lung Biomedicines chemerin neutrophil lung cancer COPD |
| title | The Role of Chemerin in Neutrophil Activation and Diseases of the Lung |
| title_full | The Role of Chemerin in Neutrophil Activation and Diseases of the Lung |
| title_fullStr | The Role of Chemerin in Neutrophil Activation and Diseases of the Lung |
| title_full_unstemmed | The Role of Chemerin in Neutrophil Activation and Diseases of the Lung |
| title_short | The Role of Chemerin in Neutrophil Activation and Diseases of the Lung |
| title_sort | role of chemerin in neutrophil activation and diseases of the lung |
| topic | chemerin neutrophil lung cancer COPD |
| url | https://www.mdpi.com/2227-9059/13/6/1354 |
| work_keys_str_mv | AT patrickarndt theroleofchemerininneutrophilactivationanddiseasesofthelung AT patrickarndt roleofchemerininneutrophilactivationanddiseasesofthelung |