Transmission selects for HIV-1 strains of intermediate virulence: a modelling approach.
Recent data shows that HIV-1 is characterised by variation in viral virulence factors that is heritable between infections, which suggests that viral virulence can be naturally selected at the population level. A trade-off between transmissibility and duration of infection appears to favour viruses...
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| Main Authors: | George Shirreff, Lorenzo Pellis, Oliver Laeyendecker, Christophe Fraser |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-10-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002185&type=printable |
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