High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2017/7296467 |
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| author | Sarah S. Al-Otaibi Faiza Alotaibi Yaseer Al Zaher Nabil Al Zaher M. A. Dababo |
| author_facet | Sarah S. Al-Otaibi Faiza Alotaibi Yaseer Al Zaher Nabil Al Zaher M. A. Dababo |
| author_sort | Sarah S. Al-Otaibi |
| collection | DOAJ |
| description | Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology. |
| format | Article |
| id | doaj-art-2546f5155c974fb8b49aa7fcc25c1de6 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-2546f5155c974fb8b49aa7fcc25c1de62025-02-03T01:02:07ZengWileyCase Reports in Otolaryngology2090-67652090-67732017-01-01201710.1155/2017/72964677296467High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual VariantSarah S. Al-Otaibi0Faiza Alotaibi1Yaseer Al Zaher2Nabil Al Zaher3M. A. Dababo4Department of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Pathology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaAcinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.http://dx.doi.org/10.1155/2017/7296467 |
| spellingShingle | Sarah S. Al-Otaibi Faiza Alotaibi Yaseer Al Zaher Nabil Al Zaher M. A. Dababo High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant Case Reports in Otolaryngology |
| title | High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant |
| title_full | High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant |
| title_fullStr | High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant |
| title_full_unstemmed | High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant |
| title_short | High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant |
| title_sort | high grade transformation dedifferentiation of acinic cell carcinoma of the parotid gland report of an unusual variant |
| url | http://dx.doi.org/10.1155/2017/7296467 |
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