Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiomyocyte Damage

Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiomyocyte Damage

Cardiac injury after severe trauma is associated with higher mortality in polytrauma patients. Recent evidence suggests that miRNAs play a key role in cardiac pathophysiology and could serve as potential markers of cardiac damage after polytrauma. To explore this hypothesis, plasma miRNA profiles fr...

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Bibliographic Details
Main Authors: Jiaoyan Han, Liudmila Leppik, Larissa Sztulman, Roberta De Rosa, Victoria Pfeiffer, Lewin-Caspar Busse, Elena Kontaxi, Elisabeth Adam, Dirk Henrich, Ingo Marzi, Birte Weber
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
polytrauma
cardiac damage
miRNA
troponin T
NLRP3
caspase
Online Access:https://www.mdpi.com/2073-4409/14/4/300
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