The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer

The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer

Abstract Prostate cancer that is resistant to anti-androgen treatment, such as enzalutamide, represents a therapeutic challenge. To study their molecular and functional features, the enzalutamide-resistant PCa cell lines LNCaP Abl EnzR and DuCaP EnzR constitute valuable in vitro models. In this work...

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Bibliographic Details
Main Authors: Juan Guzman, Martin Hart, Katrin Weigelt, Angela Neumann, Achim Aigner, Chiara Andolfi, Florian Handle, Stefanie Rheinheimer, Ulrike Fischer, Uta D. Immel, Verena Lieb, Eckart Meese, Zoran Culig, Bernd Wullich, Helge Taubert, Sven Wach
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Prostate cancer
MiRNA
MED12
Cell viability
Protein expression
Androgen receptor
Online Access:https://doi.org/10.1038/s41598-025-95250-0
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