Takayasu arteritis beyond the young: What to consider?
Background: Takayasu arteritis (TA), also known as the pulseless disease, is a rare systemic inflammatory condition that damages medium and larger arteries. With an incidence rate of 2–6 per million, it predominantly affects individuals aged 20–40. Clinical manifestations vary from asymptomatic case...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Annals of Vascular Surgery - Brief Reports and Innovations |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772687825000029 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041645977829376 |
|---|---|
| author | Suci Indriani Averina Geffanie Suwana Suko Adiarto Taofan Ruth Grace Aurora Iwan Dakota |
| author_facet | Suci Indriani Averina Geffanie Suwana Suko Adiarto Taofan Ruth Grace Aurora Iwan Dakota |
| author_sort | Suci Indriani |
| collection | DOAJ |
| description | Background: Takayasu arteritis (TA), also known as the pulseless disease, is a rare systemic inflammatory condition that damages medium and larger arteries. With an incidence rate of 2–6 per million, it predominantly affects individuals aged 20–40. Clinical manifestations vary from asymptomatic cases to severe vascular damage, often complicating diagnosis. This report aims to shed light on diagnosing Takayasu arteritis in older women. Case Summary: A 57-year-old Southeast Asian woman presented with intermittent claudication of the upper and lower limbs. Examination revealed a significant systolic blood pressure discrepancy of 60 mmHg between the left and right leg, and vascular bruits over the subclavian arteries. Laboratory tests showed high inflammatory markers and positive ANA. Imaging with duplex ultrasound and CT scan revealed total occlusion of bilateral superficial femoral artery and stenosis of the subclavian arteries. Based on the findings, the patient was diagnosed with Takayasu arteritis. Treatment with high-dose corticosteroids and methotrexate (Methotrexate), along with antihypertensive and antiplatelet drugs, led to symptom improvement and no adverse events at the 1-year follow-up. Discussion: Takayasu arteritis, while primarily affecting the young, can manifest in older individuals, presenting diagnostic challenges due to its rarity and non-specific symptoms. This case underscores the importance of including TA in the differential diagnosis for older patients with vascular symptoms. Individualized and tailored management of immunosuppressive therapy and regular monitoring are essential to control disease progression and improve outcomes. |
| format | Article |
| id | doaj-art-2535f0230e814dadbf2847cfd6cf0271 |
| institution | DOAJ |
| issn | 2772-6878 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Vascular Surgery - Brief Reports and Innovations |
| spelling | doaj-art-2535f0230e814dadbf2847cfd6cf02712025-08-20T02:55:44ZengElsevierAnnals of Vascular Surgery - Brief Reports and Innovations2772-68782025-03-015110036110.1016/j.avsurg.2025.100361Takayasu arteritis beyond the young: What to consider?Suci Indriani0Averina Geffanie Suwana1Suko Adiarto2 Taofan3Ruth Grace Aurora4Iwan Dakota5Departement of Cardiology and Vascular Medicine, Harapan Kita National Cardiovascular Center, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; Corresponding author at: Jl. Letjen S. Parman St No.Kav. 87, Slipi, Palmerah, West Jakarta City, Jakarta 11420, Indonesia.Faculty of Medicine, Universitas Indonesia, IndonesiaDepartement of Cardiology and Vascular Medicine, Harapan Kita National Cardiovascular Center, Indonesia; Faculty of Medicine, Universitas Indonesia, IndonesiaDepartement of Cardiology and Vascular Medicine, Harapan Kita National Cardiovascular Center, Indonesia; Faculty of Medicine, Universitas Indonesia, IndonesiaDepartement of Cardiology and Vascular Medicine, Harapan Kita National Cardiovascular Center, Indonesia; Faculty of Medicine, Universitas Indonesia, IndonesiaDepartement of Cardiology and Vascular Medicine, Harapan Kita National Cardiovascular Center, Indonesia; Faculty of Medicine, Universitas Indonesia, IndonesiaBackground: Takayasu arteritis (TA), also known as the pulseless disease, is a rare systemic inflammatory condition that damages medium and larger arteries. With an incidence rate of 2–6 per million, it predominantly affects individuals aged 20–40. Clinical manifestations vary from asymptomatic cases to severe vascular damage, often complicating diagnosis. This report aims to shed light on diagnosing Takayasu arteritis in older women. Case Summary: A 57-year-old Southeast Asian woman presented with intermittent claudication of the upper and lower limbs. Examination revealed a significant systolic blood pressure discrepancy of 60 mmHg between the left and right leg, and vascular bruits over the subclavian arteries. Laboratory tests showed high inflammatory markers and positive ANA. Imaging with duplex ultrasound and CT scan revealed total occlusion of bilateral superficial femoral artery and stenosis of the subclavian arteries. Based on the findings, the patient was diagnosed with Takayasu arteritis. Treatment with high-dose corticosteroids and methotrexate (Methotrexate), along with antihypertensive and antiplatelet drugs, led to symptom improvement and no adverse events at the 1-year follow-up. Discussion: Takayasu arteritis, while primarily affecting the young, can manifest in older individuals, presenting diagnostic challenges due to its rarity and non-specific symptoms. This case underscores the importance of including TA in the differential diagnosis for older patients with vascular symptoms. Individualized and tailored management of immunosuppressive therapy and regular monitoring are essential to control disease progression and improve outcomes.http://www.sciencedirect.com/science/article/pii/S2772687825000029Takayasu arteritis;VasculitisCardiovascular diseaseinflammatory |
| spellingShingle | Suci Indriani Averina Geffanie Suwana Suko Adiarto Taofan Ruth Grace Aurora Iwan Dakota Takayasu arteritis beyond the young: What to consider? Annals of Vascular Surgery - Brief Reports and Innovations Takayasu arteritis;Vasculitis Cardiovascular disease inflammatory |
| title | Takayasu arteritis beyond the young: What to consider? |
| title_full | Takayasu arteritis beyond the young: What to consider? |
| title_fullStr | Takayasu arteritis beyond the young: What to consider? |
| title_full_unstemmed | Takayasu arteritis beyond the young: What to consider? |
| title_short | Takayasu arteritis beyond the young: What to consider? |
| title_sort | takayasu arteritis beyond the young what to consider |
| topic | Takayasu arteritis;Vasculitis Cardiovascular disease inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2772687825000029 |
| work_keys_str_mv | AT suciindriani takayasuarteritisbeyondtheyoungwhattoconsider AT averinageffaniesuwana takayasuarteritisbeyondtheyoungwhattoconsider AT sukoadiarto takayasuarteritisbeyondtheyoungwhattoconsider AT taofan takayasuarteritisbeyondtheyoungwhattoconsider AT ruthgraceaurora takayasuarteritisbeyondtheyoungwhattoconsider AT iwandakota takayasuarteritisbeyondtheyoungwhattoconsider |