Bilateral breast metastases from rectal malignant melanoma: case report and literature review
Rectal melanoma is an extremely rare and highly aggressive disease, and rectal melanoma metastasis to the breast is rare. This is a 48-year-old female who presented with rectal melanoma carcinoma Following the diagnosis of locally advanced rectal cancer (TxN3M0), she received chemotherapy, immunothe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1565838/full |
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| author | Hui Liu Qian Liu Linshen Zhang Qinghua Liu Hao Cheng Jian Liao Zhaohong Chen Dingyu Lu Dingyu Lu |
| author_facet | Hui Liu Qian Liu Linshen Zhang Qinghua Liu Hao Cheng Jian Liao Zhaohong Chen Dingyu Lu Dingyu Lu |
| author_sort | Hui Liu |
| collection | DOAJ |
| description | Rectal melanoma is an extremely rare and highly aggressive disease, and rectal melanoma metastasis to the breast is rare. This is a 48-year-old female who presented with rectal melanoma carcinoma Following the diagnosis of locally advanced rectal cancer (TxN3M0), she received chemotherapy, immunotherapy with radiotherapy, and metastases to the lung, bone and vulvar developed during the therapy. After one year of treatment, the patient developed bilateral breast metastases. Then breast site was identified using the gene expression assay which showed KIT mutation, indicating sensitivity to imatinib, so the patient had used imatinib for 2 months. But then the patient started to take Chinese medicine for personally reason. Sadly, the patient passed away 22 months after initial diagnosis due to rapidly progressive disease. This case showed a rare presentation of rectal melanoma metastasis to the breast. To our knowledge, this is also the first report of rectal melanoma metastasis to bilateral breasts. |
| format | Article |
| id | doaj-art-252ed98133c347ac9df16dd88a89165c |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-252ed98133c347ac9df16dd88a89165c2025-08-20T04:02:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15658381565838Bilateral breast metastases from rectal malignant melanoma: case report and literature reviewHui Liu0Qian Liu1Linshen Zhang2Qinghua Liu3Hao Cheng4Jian Liao5Zhaohong Chen6Dingyu Lu7Dingyu Lu8Department of Oncology, Deyang People’s Hospital, Deyang, Sichuan, ChinaDepartment of Pathology, Deyang People’s Hospital, Deyang, Sichuan, ChinaMolecular Oncology Laboratory, Technical University of Munich and Klinikum Rechts der Isar, Munich, GermanyDepartment of Oncology, Deyang People’s Hospital, Deyang, Sichuan, ChinaDepartment of Oncology, Deyang People’s Hospital, Deyang, Sichuan, ChinaIntensive Care Unit, Deyang People’s Hospital, Deyang, Sichuan, ChinaDepartment of Oncology, Deyang People’s Hospital, Deyang, Sichuan, ChinaDepartment of Oncology, Deyang People’s Hospital, Deyang, Sichuan, ChinaMolecular Oncology Laboratory, Technical University of Munich and Klinikum Rechts der Isar, Munich, GermanyRectal melanoma is an extremely rare and highly aggressive disease, and rectal melanoma metastasis to the breast is rare. This is a 48-year-old female who presented with rectal melanoma carcinoma Following the diagnosis of locally advanced rectal cancer (TxN3M0), she received chemotherapy, immunotherapy with radiotherapy, and metastases to the lung, bone and vulvar developed during the therapy. After one year of treatment, the patient developed bilateral breast metastases. Then breast site was identified using the gene expression assay which showed KIT mutation, indicating sensitivity to imatinib, so the patient had used imatinib for 2 months. But then the patient started to take Chinese medicine for personally reason. Sadly, the patient passed away 22 months after initial diagnosis due to rapidly progressive disease. This case showed a rare presentation of rectal melanoma metastasis to the breast. To our knowledge, this is also the first report of rectal melanoma metastasis to bilateral breasts.https://www.frontiersin.org/articles/10.3389/fonc.2025.1565838/fullrectal malignant melanomasecondary malignant tumor of the breastmalignant melanomabreast metastasiscase report |
| spellingShingle | Hui Liu Qian Liu Linshen Zhang Qinghua Liu Hao Cheng Jian Liao Zhaohong Chen Dingyu Lu Dingyu Lu Bilateral breast metastases from rectal malignant melanoma: case report and literature review Frontiers in Oncology rectal malignant melanoma secondary malignant tumor of the breast malignant melanoma breast metastasis case report |
| title | Bilateral breast metastases from rectal malignant melanoma: case report and literature review |
| title_full | Bilateral breast metastases from rectal malignant melanoma: case report and literature review |
| title_fullStr | Bilateral breast metastases from rectal malignant melanoma: case report and literature review |
| title_full_unstemmed | Bilateral breast metastases from rectal malignant melanoma: case report and literature review |
| title_short | Bilateral breast metastases from rectal malignant melanoma: case report and literature review |
| title_sort | bilateral breast metastases from rectal malignant melanoma case report and literature review |
| topic | rectal malignant melanoma secondary malignant tumor of the breast malignant melanoma breast metastasis case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1565838/full |
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