Dialysis-related amyloidosis: a review from case series
Abstract In Japan, dialysis first started in 1963 with intermittent peritoneal dialysis, followed by hemodialysis in 1966. The introduction of dialysis made it possible to treat end-stage renal failure, which at that time was a fatal or malignant disease, making it a benign disease and enabling long...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Renal Replacement Therapy |
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| Online Access: | https://doi.org/10.1186/s41100-025-00606-x |
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| author | Yoshifumi Ubara Tatsuya Suwabe Takehiko Wada Naoki Sawa |
| author_facet | Yoshifumi Ubara Tatsuya Suwabe Takehiko Wada Naoki Sawa |
| author_sort | Yoshifumi Ubara |
| collection | DOAJ |
| description | Abstract In Japan, dialysis first started in 1963 with intermittent peritoneal dialysis, followed by hemodialysis in 1966. The introduction of dialysis made it possible to treat end-stage renal failure, which at that time was a fatal or malignant disease, making it a benign disease and enabling long-term survival. However, patients who survived on dialysis for more than 10 years often developed dialysis-related amyloidosis (DRA), a serious dialysis complication that causes bone and joint lesions such as carpal tunnel syndrome, cervical destructive spondyloarthropathy (DSA), and lumbar DSA. DRA led to impaired activities of daily living (ADL) and quality of life (QOL), and ultimately, death. Because DRA was caused by the deposition of beta-2 microglobulin (β2MG), treatment methods were devised to remove serum β2MG, i.e., dialysis fluid was purified, dialyzers with dialysis membranes were developed, and hemodiafiltration was introduced. These approaches not only greatly reduced the β2MG concentration in the blood, but they also significantly increased the number of years until the onset of DRA and decreased the amount of deposited amyloid. Unfortunately, continuous ambulatory peritoneal dialysis (CAPD) removes less β2MG than hemodialysis and patients who undergo CAPD for more than ten years can develop lumbar DSA, which decreases their ADL and can cause death. This article describes the history of treatment of dialysis amyloidosis at our hospital, a pioneering institution for dialysis in Japan, with reference to relevant publications. |
| format | Article |
| id | doaj-art-252d657718ac4a93934de828fa47ed45 |
| institution | DOAJ |
| issn | 2059-1381 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Renal Replacement Therapy |
| spelling | doaj-art-252d657718ac4a93934de828fa47ed452025-08-20T03:03:23ZengBMCRenal Replacement Therapy2059-13812025-02-0111111210.1186/s41100-025-00606-xDialysis-related amyloidosis: a review from case seriesYoshifumi Ubara0Tatsuya Suwabe1Takehiko Wada2Naoki Sawa3Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon HospitalNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon HospitalNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon HospitalNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon HospitalAbstract In Japan, dialysis first started in 1963 with intermittent peritoneal dialysis, followed by hemodialysis in 1966. The introduction of dialysis made it possible to treat end-stage renal failure, which at that time was a fatal or malignant disease, making it a benign disease and enabling long-term survival. However, patients who survived on dialysis for more than 10 years often developed dialysis-related amyloidosis (DRA), a serious dialysis complication that causes bone and joint lesions such as carpal tunnel syndrome, cervical destructive spondyloarthropathy (DSA), and lumbar DSA. DRA led to impaired activities of daily living (ADL) and quality of life (QOL), and ultimately, death. Because DRA was caused by the deposition of beta-2 microglobulin (β2MG), treatment methods were devised to remove serum β2MG, i.e., dialysis fluid was purified, dialyzers with dialysis membranes were developed, and hemodiafiltration was introduced. These approaches not only greatly reduced the β2MG concentration in the blood, but they also significantly increased the number of years until the onset of DRA and decreased the amount of deposited amyloid. Unfortunately, continuous ambulatory peritoneal dialysis (CAPD) removes less β2MG than hemodialysis and patients who undergo CAPD for more than ten years can develop lumbar DSA, which decreases their ADL and can cause death. This article describes the history of treatment of dialysis amyloidosis at our hospital, a pioneering institution for dialysis in Japan, with reference to relevant publications.https://doi.org/10.1186/s41100-025-00606-xHemodialysis (HD)Dialysis-related amyloidosis (DRA)Destructive spondyloarthropathy (DSA) |
| spellingShingle | Yoshifumi Ubara Tatsuya Suwabe Takehiko Wada Naoki Sawa Dialysis-related amyloidosis: a review from case series Renal Replacement Therapy Hemodialysis (HD) Dialysis-related amyloidosis (DRA) Destructive spondyloarthropathy (DSA) |
| title | Dialysis-related amyloidosis: a review from case series |
| title_full | Dialysis-related amyloidosis: a review from case series |
| title_fullStr | Dialysis-related amyloidosis: a review from case series |
| title_full_unstemmed | Dialysis-related amyloidosis: a review from case series |
| title_short | Dialysis-related amyloidosis: a review from case series |
| title_sort | dialysis related amyloidosis a review from case series |
| topic | Hemodialysis (HD) Dialysis-related amyloidosis (DRA) Destructive spondyloarthropathy (DSA) |
| url | https://doi.org/10.1186/s41100-025-00606-x |
| work_keys_str_mv | AT yoshifumiubara dialysisrelatedamyloidosisareviewfromcaseseries AT tatsuyasuwabe dialysisrelatedamyloidosisareviewfromcaseseries AT takehikowada dialysisrelatedamyloidosisareviewfromcaseseries AT naokisawa dialysisrelatedamyloidosisareviewfromcaseseries |