Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer

Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer

Abstract Background Alanine Serine Cysteine transporter 2 (ASCT2/SLC1A5) is a key glutamine transporter in cancer cells and has been shown in a variety of cancers to promote tumor growth by reprogramming glutamine metabolism and altering the tumor microenvironment. However, the role in thyroid cance...

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Bibliographic Details
Main Authors: Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou, Xingdang Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
SLC1A5
Thyroid cancer
Transcriptomics
Metabolomics
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12885-025-14123-x
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