Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study
Purpose: To study the clinical efficacy of a combination of 0.1% sodium hyaluronate and ectoine, added to conventional therapy, in stabilizing tear film and treating dry eye disease (DED) resulting from cataract surgery (phacoemulsification). Methods: This hospital-based comparative randomized longi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Clinical Ophthalmology and Research |
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| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_203_24 |
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| author | Disha Sahoo Jasmita Satapathy Suprava Das Pradeep Kumar Panigrahi |
| author_facet | Disha Sahoo Jasmita Satapathy Suprava Das Pradeep Kumar Panigrahi |
| author_sort | Disha Sahoo |
| collection | DOAJ |
| description | Purpose:
To study the clinical efficacy of a combination of 0.1% sodium hyaluronate and ectoine, added to conventional therapy, in stabilizing tear film and treating dry eye disease (DED) resulting from cataract surgery (phacoemulsification).
Methods:
This hospital-based comparative randomized longitudinal study included all patients above 40 years, diagnosed with cataracts, and posted for phacoemulsification surgery. DED tests performed were Ocular Surface Disease Index (OSDI) score, Schirmer's test (ST) I, tear breakup time (TBUT), and corneal fluorescein staining (CFS). Patients were randomized to study and control groups. Tests were done at baseline, 1 week, and 1 month following surgery.
Results:
One hundred and ten patients were included in the study and divided equally into two groups. The mean age in the study and control groups was 60 ± 9.53 and 61.58 ± 6.88 years, respectively. The majority of the patients in both the groups were male. At 1-month follow-up, the OSDI score was significantly higher in the control group than in the study group (P < 0.001). Around 25.45% of patients developed dry eye symptoms at 1 week and 10.91% at the end of 1 month after surgery (P < 0.001) in the control group. A higher number of patients in the control group had CFS Grade II following cataract surgery. TBUT and ST scores returned to baseline levels at the end of 1 month in the study group only.
Conclusion:
Tear substitutes containing sodium hyaluronate and ectoine benefit tear film stability, thereby improving ocular surface health following phacoemulsification. |
| format | Article |
| id | doaj-art-252b987a13764015b2fa3df189e7a10c |
| institution | OA Journals |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-252b987a13764015b2fa3df189e7a10c2025-08-20T02:32:04ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-04-0113217017610.4103/jcor.jcor_203_24Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled studyDisha SahooJasmita SatapathySuprava DasPradeep Kumar PanigrahiPurpose: To study the clinical efficacy of a combination of 0.1% sodium hyaluronate and ectoine, added to conventional therapy, in stabilizing tear film and treating dry eye disease (DED) resulting from cataract surgery (phacoemulsification). Methods: This hospital-based comparative randomized longitudinal study included all patients above 40 years, diagnosed with cataracts, and posted for phacoemulsification surgery. DED tests performed were Ocular Surface Disease Index (OSDI) score, Schirmer's test (ST) I, tear breakup time (TBUT), and corneal fluorescein staining (CFS). Patients were randomized to study and control groups. Tests were done at baseline, 1 week, and 1 month following surgery. Results: One hundred and ten patients were included in the study and divided equally into two groups. The mean age in the study and control groups was 60 ± 9.53 and 61.58 ± 6.88 years, respectively. The majority of the patients in both the groups were male. At 1-month follow-up, the OSDI score was significantly higher in the control group than in the study group (P < 0.001). Around 25.45% of patients developed dry eye symptoms at 1 week and 10.91% at the end of 1 month after surgery (P < 0.001) in the control group. A higher number of patients in the control group had CFS Grade II following cataract surgery. TBUT and ST scores returned to baseline levels at the end of 1 month in the study group only. Conclusion: Tear substitutes containing sodium hyaluronate and ectoine benefit tear film stability, thereby improving ocular surface health following phacoemulsification.https://journals.lww.com/10.4103/jcor.jcor_203_24dry eyeectoinephacoemulsificationsodium hyaluronatetear substitutes |
| spellingShingle | Disha Sahoo Jasmita Satapathy Suprava Das Pradeep Kumar Panigrahi Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study Journal of Clinical Ophthalmology and Research dry eye ectoine phacoemulsification sodium hyaluronate tear substitutes |
| title | Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study |
| title_full | Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study |
| title_fullStr | Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study |
| title_full_unstemmed | Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study |
| title_short | Efficacy of 0.1% sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification: A randomized controlled study |
| title_sort | efficacy of 0 1 sodium hyaluronate combined with ectoine in the treatment of dry eye after phacoemulsification a randomized controlled study |
| topic | dry eye ectoine phacoemulsification sodium hyaluronate tear substitutes |
| url | https://journals.lww.com/10.4103/jcor.jcor_203_24 |
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