Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab
We formulate a dynamic model of vascular tumor growth, in which the interdependence of vascular dynamics with tumor volume is considered. The model describes the angiogenic switch; thus the inhibition of the vascularization process by antiangiogenic drugs may be taken into account explicitly. We val...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2019/9079104 |
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| _version_ | 1832564455297253376 |
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| author | Dávid Csercsik Levente Kovács |
| author_facet | Dávid Csercsik Levente Kovács |
| author_sort | Dávid Csercsik |
| collection | DOAJ |
| description | We formulate a dynamic model of vascular tumor growth, in which the interdependence of vascular dynamics with tumor volume is considered. The model describes the angiogenic switch; thus the inhibition of the vascularization process by antiangiogenic drugs may be taken into account explicitly. We validate the model against volume measurement data originating from experiments on mice and analyze the model behavior assuming different inputs corresponding to different therapies. Furthermore, we show that a simple extension of the model is capable of considering cytotoxic and antiangiogenic drugs as inputs simultaneously in qualitatively different ways. |
| format | Article |
| id | doaj-art-2524683d294f4557a77f405804235f91 |
| institution | Kabale University |
| issn | 1076-2787 1099-0526 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-2524683d294f4557a77f405804235f912025-02-03T01:10:55ZengWileyComplexity1076-27871099-05262019-01-01201910.1155/2019/90791049079104Dynamic Modeling of the Angiogenic Switch and Its Inhibition by BevacizumabDávid Csercsik0Levente Kovács1Physiological Controls Research Center, University Research, Innovation and Service Center, Óbuda University, Budapest, HungaryPhysiological Controls Research Center, University Research, Innovation and Service Center, Óbuda University, Budapest, HungaryWe formulate a dynamic model of vascular tumor growth, in which the interdependence of vascular dynamics with tumor volume is considered. The model describes the angiogenic switch; thus the inhibition of the vascularization process by antiangiogenic drugs may be taken into account explicitly. We validate the model against volume measurement data originating from experiments on mice and analyze the model behavior assuming different inputs corresponding to different therapies. Furthermore, we show that a simple extension of the model is capable of considering cytotoxic and antiangiogenic drugs as inputs simultaneously in qualitatively different ways.http://dx.doi.org/10.1155/2019/9079104 |
| spellingShingle | Dávid Csercsik Levente Kovács Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab Complexity |
| title | Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab |
| title_full | Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab |
| title_fullStr | Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab |
| title_full_unstemmed | Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab |
| title_short | Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab |
| title_sort | dynamic modeling of the angiogenic switch and its inhibition by bevacizumab |
| url | http://dx.doi.org/10.1155/2019/9079104 |
| work_keys_str_mv | AT davidcsercsik dynamicmodelingoftheangiogenicswitchanditsinhibitionbybevacizumab AT leventekovacs dynamicmodelingoftheangiogenicswitchanditsinhibitionbybevacizumab |